John Mekalanos, PhD
Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate.
Authors: Authors: Griffin TJ, Thanawastien A, Cartee RT, Mekalanos JJ, Killeen KP.
Hum Vaccin Immunother
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Hum Vaccin Immunother
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Type VI secretion system sheaths as nanoparticles for antigen display.
Authors: Authors: Del Tordello E, Danilchanka O, McCluskey AJ, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing.
Authors: Authors: Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence.
Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins.
Authors: Authors: Rui H, Ritchie JM, Bronson RT, Mekalanos JJ, Zhang Y, Waldor MK.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin.
Authors: Authors: Pukatzki S, Ma AT, Revel AT, Sturtevant D, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system.
Authors: Authors: Pukatzki S, Ma AT, Sturtevant D, Krastins B, Sarracino D, Nelson WC, Heidelberg JF, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Molecular cloning and characterization of two Helicobacter pylori genes coding for plasminogen-binding proteins.
Authors: Authors: Jönsson K, Guo BP, Monstein HJ, Mekalanos JJ, Kronvall G.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease.
Authors: Authors: Dziejman M, Balon E, Boyd D, Fraser CM, Heidelberg JF, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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TnAraOut, a transposon-based approach to identify and characterize essential bacterial genes.