John Mekalanos, PhD
Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer.
Type VI secretion requires a dynamic contractile phage tail-like structure.
Authors: Authors: Basler M, Pilhofer M, Henderson GP, Jensen GJ, Mekalanos JJ.
Nature
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Nature
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In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation.
Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa.
Authors: Authors: Mougous JD, Gifford CA, Ramsdell TL, Mekalanos JJ.
Nat Cell Biol
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Nat Cell Biol
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Bile acids stimulate biofilm formation in Vibrio cholerae.
Authors: Authors: Hung DT, Zhu J, Sturtevant D, Mekalanos JJ.
Mol Microbiol
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Mol Microbiol
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The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase.
Authors: Authors: Vance RE, Hong S, Gronert K, Serhan CN, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae.
Authors: Authors: Akerley BJ, Rubin EJ, Novick VL, Amaya K, Judson N, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Isolation of peptide aptamers that inhibit intracellular processes.
Authors: Authors: Blum JH, Dove SL, Hochschild A, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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In vivo transduction with shiga toxin 1-encoding phage.
Authors: Authors: Acheson DW, Reidl J, Zhang X, Keusch GT, Mekalanos JJ, Waldor MK.
Infect Immun
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Infect Immun
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Lysogenic conversion by a filamentous phage encoding cholera toxin.