John Mekalanos, PhD

Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Emergence of a new cholera pandemic: molecular analysis of virulence determinants in Vibrio cholerae O139 and development of a live vaccine prototype.
Authors: Authors: Waldor MK, Mekalanos JJ.
J Infect Dis
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Selection of bacterial virulence genes that are specifically induced in host tissues.
Authors: Authors: Mahan MJ, Slauch JM, Mekalanos JJ.
Science
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New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection.
Authors: Authors: Winner L, Mack J, Weltzin R, Mekalanos JJ, Kraehenbuhl JP, Neutra MR.
Infect Immun
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Coordinate regulation and sensory transduction in the control of bacterial virulence.
Authors: Authors: Miller JF, Mekalanos JJ, Falkow S.
Science
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Iron regulation of Shiga-like toxin expression in Escherichia coli is mediated by the fur locus.
Authors: Authors: Calderwood SB, Mekalanos JJ.
J Bacteriol
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Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development.
Authors: Authors: Mekalanos JJ, Swartz DJ, Pearson GD, Harford N, Groyne F, de Wilde M.
Nature
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Sensing of intracellular Hcp levels controls T6SS expression in Vibrio cholerae.
Authors: Authors: Manera K, Caro F, Li H, Pei TT, Hersch SJ, Mekalanos JJ, Dong TG.
Proc Natl Acad Sci U S A
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Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.
Authors: Authors: Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ.
Nature
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Fitness cost of antibiotic susceptibility during bacterial infection.
Authors: Authors: Roux D, Danilchanka O, Guillard T, Cattoir V, Aschard H, Fu Y, Angoulvant F, Messika J, Ricard JD, Mekalanos JJ, Lory S, Pier GB, Skurnik D.
Sci Transl Med
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Vaccine economics: what price human life?
Authors: Authors: Mekalanos JJ.
Sci Transl Med
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