John Mekalanos, PhD

Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
The Vibrio cholerae O139 serogroup antigen includes an O-antigen capsule and lipopolysaccharide virulence determinants.
Authors: Authors: Waldor MK, Colwell R, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Selection for bacterial genes that are specifically induced in host tissues: the hunt for virulence factors.
Authors: Authors: Mahan MJ, Slauch JM, Hanna PC, Camilli A, Tobias JW, Waldor MK, Mekalanos JJ.
Infect Agents Dis
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Regulatory cascade controls virulence in Vibrio cholerae.
Authors: Authors: DiRita VJ, Parsot C, Jander G, Mekalanos JJ.
Proc Natl Acad Sci U S A
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A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.
Authors: Authors: Miller SI, Kukral AM, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Production and purification of cholera toxin.
Authors: Authors: Mekalanos JJ.
Methods Enzymol
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Cholera toxin: genetic analysis, regulation, and role in pathogenesis.
Authors: Authors: Mekalanos JJ.
Curr Top Microbiol Immunol
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Cholera toxin promotes pathogen acquisition of host-derived nutrients.
Authors: Authors: Rivera-Chávez F, Mekalanos JJ.
Nature
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Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages.
Authors: Authors: Hoque MM, Naser IB, Bari SM, Zhu J, Mekalanos JJ, Faruque SM.
Sci Rep
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Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host.
Authors: Authors: Fu Y, Waldor MK, Mekalanos JJ.

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A hybrid approach for the automated finishing of bacterial genomes.
Authors: Authors: Bashir A, Klammer A, Robins WP, Chin CS, Webster D, Paxinos E, Hsu D, Ashby M, Wang S, Peluso P, Sebra R, Sorenson J, Bullard J, Yen J, Valdovino M, Mollova E, Luong K, Lin S, LaMay B, Joshi A, Rowe L, Frace M, Tarr CL, Turnsek M, Davis BM, Kasarskis A, Mekalanos JJ, Waldor MK, Schadt EE.
Nat Biotechnol
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