John Mekalanos, PhD

Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Nucleotide sequence and spatiotemporal expression of the Vibrio cholerae vieSAB genes during infection.
Authors: Authors: Lee SH, Angelichio MJ, Mekalanos JJ, Camilli A.
J Bacteriol
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Characterization of Vibrio cholerae bacteriophage K139 and use of a novel mini-transposon to identify a phage-encoded virulence factor.
Authors: Authors: Reidl J, Mekalanos JJ.
Mol Microbiol
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Use of genetic recombination as a reporter of gene expression.
Authors: Authors: Camilli A, Beattie DT, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Reversion of recombinant toxoids: mutations in diphtheria toxin that partially compensate for active-site deletions.
Authors: Authors: Killeen KP, Escuyer V, Mekalanos JJ, Collier RJ.
Proc Natl Acad Sci U S A
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Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium.
Authors: Authors: Miller SI, Pulkkinen WS, Selsted ME, Mekalanos JJ.
Infect Immun
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A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR.
Authors: Authors: Miller VL, Mekalanos JJ.
J Bacteriol
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Cloning of the Vibrio cholerae recA gene and construction of a Vibrio cholerae recA mutant.
Authors: Authors: Goldberg I, Mekalanos JJ.
J Bacteriol
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Enzymic activity of cholera toxin. II. Relationships to proteolytic processing, disulfide bond reduction, and subunit composition.
Authors: Authors: Mekalanos JJ, Collier RJ, Romig WR.
J Biol Chem
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CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection.
Authors: Authors: Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ.
Cell
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A live vaccine rapidly protects against cholera in an infant rabbit model.
Authors: Authors: Hubbard TP, Billings G, Dörr T, Sit B, Warr AR, Kuehl CJ, Kim M, Delgado F, Mekalanos JJ, Lewnard JA, Waldor MK.
Sci Transl Med
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