John Mekalanos, PhD

Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Monoclonal immunoglobulin A prevents adherence and invasion of polarized epithelial cell monolayers by Salmonella typhimurium.
Authors: Authors: Michetti P, Porta N, Mahan MJ, Slauch JM, Mekalanos JJ, Blum AL, Kraehenbuhl JP, Neutra MR.
Gastroenterology
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Vibrio parahaemolyticus has a homolog of the Vibrio cholerae toxRS operon that mediates environmentally induced regulation of the thermostable direct hemolysin gene.
Authors: Authors: Lin Z, Kumagai K, Baba K, Mekalanos JJ, Nishibuchi M.
J Bacteriol
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Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator.
Authors: Authors: Parsot C, Mekalanos JJ.
J Bacteriol
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Broad-host-range vectors for delivery of TnphoA: use in genetic analysis of secreted virulence determinants of Vibrio cholerae.
Authors: Authors: Taylor RK, Manoil C, Mekalanos JJ.
J Bacteriol
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Nucleotide sequence of the type A staphylococcal enterotoxin gene.
Authors: Authors: Betley MJ, Mekalanos JJ.
J Bacteriol
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Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR.
Authors: Authors: Miller VL, Mekalanos JJ.
Proc Natl Acad Sci U S A
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In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate.
Authors: Authors: Griffin TJ, Thanawastien A, Cartee RT, Mekalanos JJ, Killeen KP.
Hum Vaccin Immunother
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Type VI secretion system sheaths as nanoparticles for antigen display.
Authors: Authors: Del Tordello E, Danilchanka O, McCluskey AJ, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing.
Authors: Authors: Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB.
Proc Natl Acad Sci U S A
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Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence.
Authors: Authors: Davies BW, Bogard RW, Young TS, Mekalanos JJ.
Cell
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