John Mekalanos, PhD

Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
New attenuated derivatives of Vibrio cholerae.
Authors: Authors: Pearson GD, DiRita VJ, Goldberg MB, Boyko SA, Calderwood SB, Mekalanos JJ.
Res Microbiol
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A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR.
Authors: Authors: Miller VL, Mekalanos JJ.
J Bacteriol
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Cloning of the Vibrio cholerae recA gene and construction of a Vibrio cholerae recA mutant.
Authors: Authors: Goldberg I, Mekalanos JJ.
J Bacteriol
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Enzymic activity of cholera toxin. II. Relationships to proteolytic processing, disulfide bond reduction, and subunit composition.
Authors: Authors: Mekalanos JJ, Collier RJ, Romig WR.
J Biol Chem
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Protein covariance networks reveal interactions important to the emergence of SARS coronaviruses as human pathogens.
Authors: Authors: Robins WP, Mekalanos JJ.
bioRxiv
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Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli.
Authors: Authors: Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC.
Proc Natl Acad Sci U S A
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RS1 satellite phage promotes diversity of toxigenic Vibrio cholerae by driving CTX prophage loss and elimination of lysogenic immunity.
Authors: Authors: Kamruzzaman M, Robins WP, Bari SM, Nahar S, Mekalanos JJ, Faruque SM.
Infect Immun
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Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae.
Authors: Authors: Dong TG, Ho BT, Yoder-Himes DR, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care.
Authors: Authors: Farmer P, Almazor CP, Bahnsen ET, Barry D, Bazile J, Bloom BR, Bose N, Brewer T, Calderwood SB, Clemens JD, Cravioto A, Eustache E, Jérôme G, Gupta N, Harris JB, Hiatt HH, Holstein C, Hotez PJ, Ivers LC, Kerry VB, Koenig SP, Larocque RC, Léandre F, Lambert W, Lyon E, Mekalanos JJ, Mukherjee JS, Oswald C, Pape JW, Gretchko Prosper A, Rabinovich R, Raymonville M, Réjouit JR, Ronan LJ, Rosenberg ML, Ryan ET, Sachs JD, Sack DA, Surena C, Suri AA, Ternier R, Waldor MK, Walton D, Weigel JL.
PLoS Negl Trop Dis
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Acquisition of classical CTX prophage from Vibrio cholerae O141 by El Tor strains aided by lytic phages and chitin-induced competence.
Authors: Authors: Udden SM, Zahid MS, Biswas K, Ahmad QS, Cravioto A, Nair GB, Mekalanos JJ, Faruque SM.
Proc Natl Acad Sci U S A
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