John Mekalanos

John Mekalanos, PhD

Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School

Publications

Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins.

Authors: Authors: Rui H, Ritchie JM, Bronson RT, Mekalanos JJ, Zhang Y, Waldor MK.
Proc Natl Acad Sci U S A 2010-03-02
View full abstract on Pubmed

Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin.

Authors: Authors: Pukatzki S, Ma AT, Revel AT, Sturtevant D, Mekalanos JJ.
Proc Natl Acad Sci U S A 2007-09-25
View full abstract on Pubmed

Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system.

Authors: Authors: Pukatzki S, Ma AT, Sturtevant D, Krastins B, Sarracino D, Nelson WC, Heidelberg JF, Mekalanos JJ.
Proc Natl Acad Sci U S A 2006-01-31
View full abstract on Pubmed

Molecular cloning and characterization of two Helicobacter pylori genes coding for plasminogen-binding proteins.

Authors: Authors: Jönsson K, Guo BP, Monstein HJ, Mekalanos JJ, Kronvall G.
Proc Natl Acad Sci U S A 2004-02-17
View full abstract on Pubmed

Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease.

Authors: Authors: Dziejman M, Balon E, Boyd D, Fraser CM, Heidelberg JF, Mekalanos JJ.
Proc Natl Acad Sci U S A 2002-02-05
View full abstract on Pubmed

TnAraOut, a transposon-based approach to identify and characterize essential bacterial genes.

Authors: Authors: Judson N, Mekalanos JJ.
Nat Biotechnol 2000-07-01
View full abstract on Pubmed

Identification of multiple sigma54-dependent transcriptional activators in Vibrio cholerae.

Authors: Authors: Klose KE, Novik V, Mekalanos JJ.
J Bacteriol 1998-10-01
View full abstract on Pubmed

A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139.

Authors: Authors: Waldor MK, Tschäpe H, Mekalanos JJ.
J Bacteriol 1996-07-01
View full abstract on Pubmed

Cholera vaccines: fighting an ancient scourge.

Authors: Authors: Mekalanos JJ, Sadoff JC.
Science 1994-09-02
View full abstract on Pubmed

CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor.

Authors: Authors: Pearson GD, Woods A, Chiang SL, Mekalanos JJ.
Proc Natl Acad Sci U S A 1993-04-15
View full abstract on Pubmed