John Mekalanos, PhD
Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants.
Authors: Authors: Qadri F, Chowdhury MI, Faruque SM, Salam MA, Ahmed T, Begum YA, Saha A, Al Tarique A, Seidlein LV, Park E, Killeen KP, Mekalanos JJ, Clemens JD, Sack DA.
Vaccine
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Vaccine
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Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage.
Authors: Authors: Faruque SM, Islam MJ, Ahmad QS, Faruque AS, Sack DA, Nair GB, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients.
Authors: Authors: Bina J, Zhu J, Dziejman M, Faruque S, Calderwood S, Mekalanos J.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance.
Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage.
Authors: Authors: Lin W, Fullner KJ, Clayton R, Sexton JA, Rogers MB, Calia KE, Calderwood SB, Fraser C, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization.
Single amino acid substitutions in the N-terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance.
Authors: Authors: Chiang SL, Taylor RK, Koomey M, Mekalanos JJ.
Mol Microbiol
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Mol Microbiol
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Live attenuated vaccine vectors.
Constitutive sensory transduction mutations in the Bordetella pertussis bvgS gene.
Authors: Authors: Miller JF, Johnson SA, Black WJ, Beattie DT, Mekalanos JJ, Falkow S.
J Bacteriol
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J Bacteriol
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Salmonella vaccines with mutations in the phoP virulence regulon.