John Mekalanos, PhD
Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Helicobacter pylori mutagenesis by mariner in vitro transposition.
In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria.
Authors: Authors: Rubin EJ, Akerley BJ, Novik VN, Lampe DJ, Husson RN, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Distinct roles of an alternative sigma factor during both free-swimming and colonizing phases of the Vibrio cholerae pathogenic cycle.
Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection.
Regulation of cholera toxin by temperature, pH, and osmolarity.
Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium.
Authors: Authors: Michetti P, Mahan MJ, Slauch JM, Mekalanos JJ, Neutra MR.
Infect Immun
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Infect Immun
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New attenuated derivatives of Vibrio cholerae.
Authors: Authors: Pearson GD, DiRita VJ, Goldberg MB, Boyko SA, Calderwood SB, Mekalanos JJ.
Res Microbiol
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Res Microbiol
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A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR.
Cloning of the Vibrio cholerae recA gene and construction of a Vibrio cholerae recA mutant.
Enzymic activity of cholera toxin. II. Relationships to proteolytic processing, disulfide bond reduction, and subunit composition.