John Mekalanos, PhD
Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Protein covariance networks reveal interactions important to the emergence of SARS coronaviruses as human pathogens.
Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli.
Authors: Authors: Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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RS1 satellite phage promotes diversity of toxigenic Vibrio cholerae by driving CTX prophage loss and elimination of lysogenic immunity.
Authors: Authors: Kamruzzaman M, Robins WP, Bari SM, Nahar S, Mekalanos JJ, Faruque SM.
Infect Immun
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Infect Immun
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Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae.
Authors: Authors: Dong TG, Ho BT, Yoder-Himes DR, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care.
Authors: Authors: Farmer P, Almazor CP, Bahnsen ET, Barry D, Bazile J, Bloom BR, Bose N, Brewer T, Calderwood SB, Clemens JD, Cravioto A, Eustache E, Jérôme G, Gupta N, Harris JB, Hiatt HH, Holstein C, Hotez PJ, Ivers LC, Kerry VB, Koenig SP, Larocque RC, Léandre F, Lambert W, Lyon E, Mekalanos JJ, Mukherjee JS, Oswald C, Pape JW, Gretchko Prosper A, Rabinovich R, Raymonville M, Réjouit JR, Ronan LJ, Rosenberg ML, Ryan ET, Sachs JD, Sack DA, Surena C, Suri AA, Ternier R, Waldor MK, Walton D, Weigel JL.
PLoS Negl Trop Dis
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PLoS Negl Trop Dis
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Acquisition of classical CTX prophage from Vibrio cholerae O141 by El Tor strains aided by lytic phages and chitin-induced competence.
Authors: Authors: Udden SM, Zahid MS, Biswas K, Ahmad QS, Cravioto A, Nair GB, Mekalanos JJ, Faruque SM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants.
Authors: Authors: Qadri F, Chowdhury MI, Faruque SM, Salam MA, Ahmed T, Begum YA, Saha A, Al Tarique A, Seidlein LV, Park E, Killeen KP, Mekalanos JJ, Clemens JD, Sack DA.
Vaccine
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Vaccine
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Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage.
Authors: Authors: Faruque SM, Islam MJ, Ahmad QS, Faruque AS, Sack DA, Nair GB, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients.
Authors: Authors: Bina J, Zhu J, Dziejman M, Faruque S, Calderwood S, Mekalanos J.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance.