John Mekalanos, PhD
Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.
Coupling mutagenesis and parallel deep sequencing to probe essential residues in a genome or gene.
Authors: Authors: Robins WP, Faruque SM, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Type III secretion is essential for the rapidly fatal diarrheal disease caused by non-O1, non-O139 Vibrio cholerae.
Authors: Authors: Shin OS, Tam VC, Suzuki M, Ritchie JM, Bronson RT, Waldor MK, Mekalanos JJ.
mBio
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mBio
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Effect of phage on the infectivity of Vibrio cholerae and emergence of genetic variants.
Authors: Authors: Zahid MS, Udden SM, Faruque AS, Calderwood SB, Mekalanos JJ, Faruque SM.
Infect Immun
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Infect Immun
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2,3-butanediol synthesis and the emergence of the Vibrio cholerae El Tor biotype.
ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa.
Authors: Authors: Rietsch A, Vallet-Gely I, Dove SL, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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A constitutively active variant of the quorum-sensing regulator LuxO affects protease production and biofilm formation in Vibrio cholerae.
Helicobacter pylori mutagenesis by mariner in vitro transposition.
In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria.
Authors: Authors: Rubin EJ, Akerley BJ, Novik VN, Lampe DJ, Husson RN, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Distinct roles of an alternative sigma factor during both free-swimming and colonizing phases of the Vibrio cholerae pathogenic cycle.