John Mekalanos, PhD

Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae.
Authors: Authors: Dong TG, Ho BT, Yoder-Himes DR, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care.
Authors: Authors: Farmer P, Almazor CP, Bahnsen ET, Barry D, Bazile J, Bloom BR, Bose N, Brewer T, Calderwood SB, Clemens JD, Cravioto A, Eustache E, Jérôme G, Gupta N, Harris JB, Hiatt HH, Holstein C, Hotez PJ, Ivers LC, Kerry VB, Koenig SP, Larocque RC, Léandre F, Lambert W, Lyon E, Mekalanos JJ, Mukherjee JS, Oswald C, Pape JW, Gretchko Prosper A, Rabinovich R, Raymonville M, Réjouit JR, Ronan LJ, Rosenberg ML, Ryan ET, Sachs JD, Sack DA, Surena C, Suri AA, Ternier R, Waldor MK, Walton D, Weigel JL.
PLoS Negl Trop Dis
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Acquisition of classical CTX prophage from Vibrio cholerae O141 by El Tor strains aided by lytic phages and chitin-induced competence.
Authors: Authors: Udden SM, Zahid MS, Biswas K, Ahmad QS, Cravioto A, Nair GB, Mekalanos JJ, Faruque SM.
Proc Natl Acad Sci U S A
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Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants.
Authors: Authors: Qadri F, Chowdhury MI, Faruque SM, Salam MA, Ahmed T, Begum YA, Saha A, Al Tarique A, Seidlein LV, Park E, Killeen KP, Mekalanos JJ, Clemens JD, Sack DA.
Vaccine
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Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage.
Authors: Authors: Faruque SM, Islam MJ, Ahmad QS, Faruque AS, Sack DA, Nair GB, Mekalanos JJ.
Proc Natl Acad Sci U S A
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ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients.
Authors: Authors: Bina J, Zhu J, Dziejman M, Faruque S, Calderwood S, Mekalanos J.
Proc Natl Acad Sci U S A
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Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance.
Authors: Authors: Cassell GH, Mekalanos J.
JAMA
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Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage.
Authors: Authors: Lin W, Fullner KJ, Clayton R, Sexton JA, Rogers MB, Calia KE, Calderwood SB, Fraser C, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization.
Authors: Authors: Chiang SL, Mekalanos JJ.
Mol Microbiol
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Single amino acid substitutions in the N-terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance.
Authors: Authors: Chiang SL, Taylor RK, Koomey M, Mekalanos JJ.
Mol Microbiol
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