John Mekalanos, PhD
Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Quorum sensing and a global regulator TsrA control expression of type VI secretion and virulence in Vibrio cholerae.
Authors: Authors: Zheng J, Shin OS, Cameron DE, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Decreased potency of the Vibrio cholerae sheathed flagellum to trigger host innate immunity.
Bacterial genomics and pathogen evolution.
Authors: Authors: Raskin DM, Seshadri R, Pukatzki SU, Mekalanos JJ.
Cell
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Cell
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Seasonal epidemics of cholera inversely correlate with the prevalence of environmental cholera phages.
Authors: Authors: Faruque SM, Naser IB, Islam MJ, Faruque AS, Ghosh AN, Nair GB, Sack DA, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site.
Authors: Authors: Buddelmeijer N, Judson N, Boyd D, Mekalanos JJ, Beckwith J.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Genetic footprinting with mariner-based transposition in Pseudomonas aeruginosa.
Analysis of clinical and environmental strains of nontoxigenic Vibrio cholerae for susceptibility to CTXPhi: molecular basis for origination of new strains with epidemic potential.
Authors: Authors: Faruque SM, Saha MN, Alim AR, Albert MJ, Islam KM, Mekalanos JJ.
Infect Immun
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Infect Immun
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Simultaneous prevention of glutamine synthesis and high-affinity transport attenuates Salmonella typhimurium virulence.
Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host.
Authors: Authors: Mahan MJ, Tobias JW, Slauch JM, Hanna PC, Collier RJ, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Bacteriophage P22 transduction of integrated plasmids: single-step cloning of Salmonella typhimurium gene fusions.