John Mekalanos, PhD

Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Evidence that modulation requires sequences downstream of the promoters of two vir-repressed genes of Bordetella pertussis.
Authors: Authors: Beattie DT, Knapp S, Mekalanos JJ.
J Bacteriol
View full abstract on Pubmed
Two trans-acting regulatory genes (vir and mod) control antigenic modulation in Bordetella pertussis.
Authors: Authors: Knapp S, Mekalanos JJ.
J Bacteriol
View full abstract on Pubmed
Cholera toxin transcriptional activator toxR is a transmembrane DNA binding protein.
Authors: Authors: Miller VL, Taylor RK, Mekalanos JJ.
Cell
View full abstract on Pubmed
Regulation of cholera toxin production in Vibrio cholerae: genetic analysis of phenotypic instability in hypertoxinogenic mutants.
Authors: Authors: Mekalanos JJ, Murphy JR.
J Bacteriol
View full abstract on Pubmed
Long-term Persistence of an Extensively Drug-Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center.
Authors: Authors: Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ, Oliver A, Hauser AR.
Clin Infect Dis
View full abstract on Pubmed
The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism.
Authors: Authors: Kamareddine L, Robins WP, Berkey CD, Mekalanos JJ, Watnick PI.
Cell Metab
View full abstract on Pubmed
The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism.
Authors: Authors: Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI.

View full abstract on Pubmed
Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions.
Authors: Authors: Basler M, Ho BT, Mekalanos JJ.
Cell
View full abstract on Pubmed
Mapping the regulon of Vibrio cholerae ferric uptake regulator expands its known network of gene regulation.
Authors: Authors: Davies BW, Bogard RW, Mekalanos JJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
Authors: Authors: Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed