Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.
Authors: Authors: Ye L, Bae M, Cassilly CD, Jabba SV, Thorpe DW, Martin AM, Lu HY, Wang J, Thompson JD, Lickwar CR, Poss KD, Keating DJ, Jordt SE, Clardy J, Liddle RA, Rawls JF.
Cell Host Microbe
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Tiny crystals have big potential for determining structures of small molecules.
Authors: Authors: Brown A, Clardy J.
Nature
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Tryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete.
Authors: Authors: Wyche TP, Ruzzini AC, Schwab L, Currie CR, Clardy J.
J Am Chem Soc
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Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.
Authors: Authors: Vafai SB, Mevers E, Higgins KW, Fomina Y, Zhang J, Mandinova A, Newman D, Shaw SY, Clardy J, Mootha VK.
PLoS One
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Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts.
Authors: Authors: Cheng KC, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su XZ, Tamayo-Castillo G, Matainaho T, Clardy J, Sherman DH, Inglese J.
J Nat Prod
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Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts.
Authors: Authors: Raveh A, Schultz PJ, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, Clardy J, Neubig RR, Sherman DH, Sjögren B.
Mol Pharmacol
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X-ray crystallography: One size fits most.
Authors: Authors: Stallforth P, Clardy J.
Nature
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Small molecule perimeter defense in entomopathogenic bacteria.
Authors: Authors: Crawford JM, Portmann C, Zhang X, Roeffaers MB, Clardy J.
Proc Natl Acad Sci U S A
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Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4.
Authors: Authors: Seyedsayamdost MR, Traxler MF, Zheng SL, Kolter R, Clardy J.
J Am Chem Soc
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A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.
Authors: Authors: Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek R.
Org Lett
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