Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Parsing Molecules for Drug Discovery.
Authors: Authors: Walker AS, Pishchany G, Clardy J.
Biochemistry
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Mammalian Cells Engineered To Produce New Steroids.
Authors: Authors: Spady ES, Wyche TP, Rollins NJ, Clardy J, Way JC, Silver PA.
Chembiochem
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Natural products and morphogenic activity of ?-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata.
Authors: Authors: Guo H, Rischer M, Sperfeld M, Weigel C, Menzel KD, Clardy J, Beemelmanns C.
Bioorg Med Chem
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Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates.
Authors: Authors: Woznica A, Cantley AM, Beemelmanns C, Freinkman E, Clardy J, King N.
Proc Natl Acad Sci U S A
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Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways.
Authors: Authors: Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW.
J Biol Chem
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Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
Authors: Authors: Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, Clardy J, Lewis K.
Chem Biol
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Bactobolin resistance is conferred by mutations in the L2 ribosomal protein.
Authors: Authors: Chandler JR, Truong TT, Silva PM, Seyedsayamdost MR, Carr G, Radey M, Jacobs MA, Sims EH, Clardy J, Greenberg EP.
mBio
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A self-produced trigger for biofilm disassembly that targets exopolysaccharide.
Authors: Authors: Kolodkin-Gal I, Cao S, Chai L, Böttcher T, Kolter R, Clardy J, Losick R.
Cell
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Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.
Authors: Authors: Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E.
Antimicrob Agents Chemother
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D-amino acids trigger biofilm disassembly.
Authors: Authors: Kolodkin-Gal I, Romero D, Cao S, Clardy J, Kolter R, Losick R.
Science
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