Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Catecholate siderophores protect bacteria from pyochelin toxicity.
Authors: Authors: Adler C, Corbalán NS, Seyedsayamdost MR, Pomares MF, de Cristóbal RE, Clardy J, Kolter R, Vincent PA.
PLoS One
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A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity.
Authors: Authors: Ymele-Leki P, Cao S, Sharp J, Lambert KG, McAdam AJ, Husson RN, Tamayo G, Clardy J, Watnick PI.
PLoS One
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The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes.
Authors: Authors: Marks KM, Park ES, Arefolov A, Russo K, Ishihara K, Ring JE, Clardy J, Clarke AS, Pelish HE.
J Nat Prod
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Chemical modification of the insecticidal briantheins X and Y.
Authors: Authors: Cronan JM, Lee A, Liang J, Clardy J, Cardellina JH.
J Nat Prod
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The natural history of antibiotics.
Authors: Authors: Clardy J, Fischbach MA, Currie CR.
Curr Biol
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FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells.
Authors: Authors: Fernández de Mattos S, Villalonga P, Clardy J, Lam EW.

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High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.
Authors: Authors: Martyn DC, Jones DC, Fairlamb AH, Clardy J.
Bioorg Med Chem Lett
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Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA.
Authors: Authors: Brady SF, Clardy J.
Angew Chem Int Ed Engl
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The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.
Authors: Authors: Calero G, Gupta P, Nonato MC, Tandel S, Biehl ER, Hofmann SL, Clardy J.
J Biol Chem
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Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha.
Authors: Authors: Nonato MC, Widom J, Clardy J.
J Biol Chem
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