Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways.
Authors: Authors: Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW.
J Biol Chem
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Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
Authors: Authors: Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, Clardy J, Lewis K.
Chem Biol
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Bactobolin resistance is conferred by mutations in the L2 ribosomal protein.
Authors: Authors: Chandler JR, Truong TT, Silva PM, Seyedsayamdost MR, Carr G, Radey M, Jacobs MA, Sims EH, Clardy J, Greenberg EP.
mBio
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A self-produced trigger for biofilm disassembly that targets exopolysaccharide.
Authors: Authors: Kolodkin-Gal I, Cao S, Chai L, Böttcher T, Kolter R, Clardy J, Losick R.
Cell
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Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.
Authors: Authors: Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E.
Antimicrob Agents Chemother
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D-amino acids trigger biofilm disassembly.
Authors: Authors: Kolodkin-Gal I, Romero D, Cao S, Clardy J, Kolter R, Losick R.
Science
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An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations.
Authors: Authors: Butcher RA, Ragains JR, Clardy J.
Org Lett
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Actin-aggregating cucurbitacins from Physocarpus capitatus.
Authors: Authors: Maloney KN, Fujita M, Eggert US, Schroeder FC, Field CM, Mitchison TJ, Clardy J.
J Nat Prod
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Small-molecule pheromones that control dauer development in Caenorhabditis elegans.
Authors: Authors: Butcher RA, Fujita M, Schroeder FC, Clardy J.
Nat Chem Biol
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Stopping trouble before it starts.
Authors: Authors: Clardy J.
ACS Chem Biol
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