Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
A self-produced trigger for biofilm disassembly that targets exopolysaccharide.
Authors: Authors: Kolodkin-Gal I, Cao S, Chai L, Böttcher T, Kolter R, Clardy J, Losick R.
Cell
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Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.
Authors: Authors: Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E.
Antimicrob Agents Chemother
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D-amino acids trigger biofilm disassembly.
Authors: Authors: Kolodkin-Gal I, Romero D, Cao S, Clardy J, Kolter R, Losick R.
Science
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An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations.
Authors: Authors: Butcher RA, Ragains JR, Clardy J.
Org Lett
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Actin-aggregating cucurbitacins from Physocarpus capitatus.
Authors: Authors: Maloney KN, Fujita M, Eggert US, Schroeder FC, Field CM, Mitchison TJ, Clardy J.
J Nat Prod
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Small-molecule pheromones that control dauer development in Caenorhabditis elegans.
Authors: Authors: Butcher RA, Fujita M, Schroeder FC, Clardy J.
Nat Chem Biol
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Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Authors: Authors: Hurt DE, Sutton AE, Clardy J.
Bioorg Med Chem Lett
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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.
Authors: Authors: Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA.
Cancer Cell
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Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis.
Authors: Authors: Wagenaar MM, Gibson DM, Clardy J.
Org Lett
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Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride.
Authors: Authors: Das AK, Bellizzi JJ, Tandel S, Biehl E, Clardy J, Hofmann SL.
J Biol Chem
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