Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis.
Authors: Authors: Hiraki M, Hwang SY, Cao S, Ramadhar TR, Byun S, Yoon KW, Lee JH, Chu K, Gurkar AU, Kolev V, Zhang J, Namba T, Murphy ME, Newman DJ, Mandinova A, Clardy J, Lee SW.
Chem Biol
View full abstract on Pubmed
Synthesis of the rosette-inducing factor RIF-1 and analogs.
Authors: Authors: Beemelmanns C, Woznica A, Alegado RA, Cantley AM, King N, Clardy J.
J Am Chem Soc
View full abstract on Pubmed
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
Authors: Authors: Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.
Nat Prod Rep
View full abstract on Pubmed
Microbial genome mining answers longstanding biosynthetic questions.
Authors: Authors: Crawford JM, Clardy J.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
New naphthoquinones and a new d-lactone produced by endophytic fungi from Costa Rica.
Authors: Authors: Cao S, Clardy J.
Tetrahedron Lett
View full abstract on Pubmed
Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.
Authors: Authors: Blodgett JA, Oh DC, Cao S, Currie CR, Kolter R, Clardy J.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.
Authors: Authors: Martyn DC, Beletsky G, Cortese JF, Tyndall E, Liu H, Fitzgerald MM, O'Shea TJ, Liang B, Clardy J.
Bioorg Med Chem Lett
View full abstract on Pubmed
Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.
Authors: Authors: Martyn DC, Ramirez AP, Beattie MJ, Cortese JF, Patel V, Rush MA, Woerpel KA, Clardy J.
Bioorg Med Chem Lett
View full abstract on Pubmed
Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium.
Authors: Authors: Clardy J, Brady SF.
J Bacteriol
View full abstract on Pubmed
Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Authors: Authors: Hurt DE, Widom J, Clardy J.
Acta Crystallogr D Biol Crystallogr
View full abstract on Pubmed