Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.
Authors: Authors: Calero G, Gupta P, Nonato MC, Tandel S, Biehl ER, Hofmann SL, Clardy J.
J Biol Chem
View full abstract on Pubmed
Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha.
Authors: Authors: Nonato MC, Widom J, Clardy J.
J Biol Chem
View full abstract on Pubmed
The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis.
Authors: Authors: Bellizzi JJ, Widom J, Kemp C, Lu JY, Das AK, Hofmann SL, Clardy J.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Megathyrin B: a cytotoxic diterpene from Isodon megathyrsus.
Authors: Authors: Qiu SX, Sun HD, Lobkovsky E, Chai H, Clardy J, Farnsworth NR, Pezzuto JM, Fong HH.
Planta Med
View full abstract on Pubmed
Structure of the spiroketal-macrolide ossamycin.
Authors: Authors: Kirst HA, Mynderse JS, Martin JW, Baker PJ, Paschal JW, Rios Steiner JL, Lobkovsky E, Clardy J.
J Antibiot (Tokyo)
View full abstract on Pubmed
Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex.
Authors: Authors: Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J.
Science
View full abstract on Pubmed
Bipolaroxin, a selective phytotoxin produced by Bipolaris cynodontis.
Authors: Authors: Sugawara F, Strobel G, Fisher LE, Van Duyne GD, Clardy J.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Letter: The structure of saxitoxin.
Authors: Authors: Schantz EJ, Ghazarossian VE, Schnoes HK, Strong FM, Springer JP, Pezzanite JO, Clardy J.
J Am Chem Soc
View full abstract on Pubmed
Burkholderia from Fungus Gardens of Fungus-Growing Ants Produces Antifungals That Inhibit the Specialized Parasite Escovopsis.
Authors: Authors: Francoeur CB, May DS, Thairu MW, Hoang DQ, Panthofer O, Bugni TS, Pupo MT, Clardy J, Pinto-Tomás AA, Currie CR.
Appl Environ Microbiol
View full abstract on Pubmed
Pyonitrins A-D: Chimeric Natural Products Produced by Pseudomonas protegens.
Authors: Authors: Mevers E, Saurí J, Helfrich EJN, Henke M, Barns KJ, Bugni TS, Andes D, Currie CR, Clardy J.
J Am Chem Soc
View full abstract on Pubmed