Junying Yuan, PhD
Elizabeth D. Hay Professor of Cell Biology, Harvard Medical School
To kill or to arrest: that is the new question for Apaf-1.
Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms.
Authors: Authors: Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J.
Adv Enzyme Regul
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Adv Enzyme Regul
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Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.
Authors: Authors: Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL.
Endocrinology
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Endocrinology
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A genome-wide RNAi screen reveals multiple regulators of caspase activation.
Authors: Authors: Yi CH, Sogah DK, Boyce M, Degterev A, Christofferson DE, Yuan J.
J Cell Biol
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J Cell Biol
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A PHD finger motif in the C terminus of RAG2 modulates recombination activity.
Authors: Authors: Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP.
J Biol Chem
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J Biol Chem
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Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.
Authors: Authors: Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RA, Moskowitz MA.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors.
Authors: Authors: Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD.
Bioorg Med Chem Lett
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Bioorg Med Chem Lett
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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
Authors: Authors: Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J.
Nat Chem Biol
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Nat Chem Biol
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LKB1--a master tumour suppressor of the small intestine and beyond.
Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection.