Karen Adelman, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila.
Authors: Authors: Nechaev S, Fargo DC, dos Santos G, Liu L, Gao Y, Adelman K.
Science
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Science
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Solution structure and stability of the anti-sigma factor AsiA: implications for novel functions.
Authors: Authors: Urbauer JL, Simeonov MF, Urbauer RJ, Adelman K, Gilmore JM, Brody EN.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Transcriptional speed bumps revealed in high resolution.
Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals.
Authors: Authors: Henriques T, Gilchrist DA, Nechaev S, Bern M, Muse GW, Burkholder A, Fargo DC, Adelman K.
Mol Cell
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Mol Cell
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Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling.
Authors: Authors: Adelman K, Kennedy MA, Nechaev S, Gilchrist DA, Muse GW, Chinenov Y, Rogatsky I.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Emerging Roles of Non-Coding RNA Transcription.
Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle.
Authors: Authors: Gupte R, Muse GW, Chinenov Y, Adelman K, Rogatsky I.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Spt6 enhances the elongation rate of RNA polymerase II in vivo.
Authors: Authors: Ardehali MB, Yao J, Adelman K, Fuda NJ, Petesch SJ, Webb WW, Lis JT.
EMBO J
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EMBO J
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Transcription start site profiling uncovers divergent transcription and enhancer-associated RNAs in Drosophila melanogaster.
Authors: Authors: Meers MP, Adelman K, Duronio RJ, Strahl BD, McKay DJ, Matera AG.
BMC Genomics
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BMC Genomics
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SnapShot: Transcription regulation: pausing.