Karen Adelman, PhD

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.
Authors: Authors: Nechaev S, Adelman K.
Biochim Biophys Acta
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Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25.
Authors: Authors: Adelman K, Yuzenkova J, La Porta A, Zenkin N, Lee J, Lis JT, Borukhov S, Wang MD, Severinov K.
Mol Cell
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The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.
Authors: Authors: Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, Nechaev S, Whetstine JR, Roeder RG, Adelman K, Goren A, Mostoslavsky R.
Mol Cell
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Non-coding RNA: More uses for genomic junk.
Authors: Authors: Adelman K, Egan E.
Nature
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Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation.
Authors: Authors: Gilchrist DA, Dos Santos G, Fargo DC, Xie B, Gao Y, Li L, Adelman K.
Cell
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Probing TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes.
Authors: Authors: Fan X, Shi H, Adelman K, Lis JT.
Proc Natl Acad Sci U S A
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NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region.
Authors: Authors: Oldfield AJ, Henriques T, Kumar D, Burkholder AB, Cinghu S, Paulet D, Bennett BD, Yang P, Scruggs BS, Lavender CA, Rivals E, Adelman K, Jothi R.
Nat Commun
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Bidirectional Transcription Arises from Two Distinct Hubs of Transcription Factor Binding and Active Chromatin.
Authors: Authors: Scruggs BS, Gilchrist DA, Nechaev S, Muse GW, Burkholder A, Fargo DC, Adelman K.
Mol Cell
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CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
Authors: Authors: Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL.
Genes Dev
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Characterization of the interactions between the bacteriophage T4 AsiA protein and RNA polymerase.
Authors: Authors: Simeonov MF, Bieber Urbauer RJ, Gilmore JM, Adelman K, Brody EN, Niedziela-Majka A, Minakhin L, Heyduk T, Urbauer JL.
Biochemistry
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