Karen Adelman, PhD

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Probing TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes.
Authors: Authors: Fan X, Shi H, Adelman K, Lis JT.
Proc Natl Acad Sci U S A
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NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region.
Authors: Authors: Oldfield AJ, Henriques T, Kumar D, Burkholder AB, Cinghu S, Paulet D, Bennett BD, Yang P, Scruggs BS, Lavender CA, Rivals E, Adelman K, Jothi R.
Nat Commun
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Bidirectional Transcription Arises from Two Distinct Hubs of Transcription Factor Binding and Active Chromatin.
Authors: Authors: Scruggs BS, Gilchrist DA, Nechaev S, Muse GW, Burkholder A, Fargo DC, Adelman K.
Mol Cell
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CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
Authors: Authors: Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL.
Genes Dev
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Characterization of the interactions between the bacteriophage T4 AsiA protein and RNA polymerase.
Authors: Authors: Simeonov MF, Bieber Urbauer RJ, Gilmore JM, Adelman K, Brody EN, Niedziela-Majka A, Minakhin L, Heyduk T, Urbauer JL.
Biochemistry
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PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression.
Authors: Authors: Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete-Perea J, Sheng W, Gygi SP, Adelman K, Shi Y.
Mol Cell
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Pausing of RNA polymerase II regulates mammalian developmental potential through control of signaling networks.
Authors: Authors: Williams LH, Fromm G, Gokey NG, Henriques T, Muse GW, Burkholder A, Fargo DC, Hu G, Adelman K.
Mol Cell
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Moonshine illuminates a developmental role for regulated transcription elongation.
Authors: Authors: Gilchrist DA, Adelman K.
Dev Cell
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Interaction of T4 AsiA with its target sites in the RNA polymerase sigma70 subunit leads to distinct and opposite effects on transcription.
Authors: Authors: Minakhin L, Niedziela-Majka A, Kuznedelov K, Adelman K, Urbauer JL, Heyduk T, Severinov K.
J Mol Biol
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Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation.
Authors: Authors: Core L, Adelman K.
Genes Dev
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