Marc Kirschner, PhD

John Franklin Enders University Professor of Systems Biology, Harvard Medical School
Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated.
Authors: Authors: Ortiz-Meoz RF, Merbl Y, Kirschner MW, Walker S.
J Am Chem Soc
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Gap 1 phase length and mouse embryonic stem cell self-renewal.
Authors: Authors: Li VC, Ballabeni A, Kirschner MW.
Proc Natl Acad Sci U S A
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The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.
Authors: Authors: Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M.
Genes Dev
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Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays.
Authors: Authors: Merbl Y, Kirschner MW.
Proc Natl Acad Sci U S A
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In vitro reconstitution of cdc42-mediated actin assembly using purified components.
Authors: Authors: Ho HY, Rohatgi R, Lebensohn AM, Kirschner MW.
Methods Enzymol
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Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
Authors: Authors: Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK.
Nat Struct Mol Biol
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Oligonucleotide microarray data mining: search for age-dependent gene expression.
Authors: Authors: Kirschner M, Pujol G, Radu A.
Biochem Biophys Res Commun
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A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.
Authors: Authors: Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW.
Proc Natl Acad Sci U S A
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Easy passage: germline transgenesis in frogs.
Authors: Authors: Kroll KL, Kirschner MW.
Proc Natl Acad Sci U S A
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The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.
Authors: Authors: Fang G, Yu H, Kirschner MW.
Genes Dev
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