Marc Kirschner, PhD

John Franklin Enders University Professor of Systems Biology, Harvard Medical School
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.
Authors: Authors: Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W.
Cancer Discov
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A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.
Authors: Authors: Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G.
Cell
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Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.
Authors: Authors: Ballabeni A, Zamponi R, Moore JK, Helin K, Kirschner MW.
Proc Natl Acad Sci U S A
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Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis.
Authors: Authors: Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A.
Development
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An inducible Tet-Off-H2B-GFP lentiviral reporter vector for detection and in vivo isolation of label-retaining cells.
Authors: Authors: Falkowska-Hansen B, Kollar J, Grüner BM, Schanz M, Boukamp P, Siveke J, Rethwilm A, Kirschner M.
Exp Cell Res
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The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo.
Authors: Authors: Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, Waddell S, Lee LA.
J Cell Sci
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Hemichordates and the origin of chordates.
Authors: Authors: Gerhart J, Lowe C, Kirschner M.
Curr Opin Genet Dev
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The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex.
Authors: Authors: Song MS, Song SJ, Ayad NG, Chang JS, Lee JH, Hong HK, Lee H, Choi N, Kim J, Kim H, Kim JW, Choi EJ, Kirschner MW, Lim DS.
Nat Cell Biol
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A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.
Authors: Authors: Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO.
J Biol Chem
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Information access. Building a "GenBank" of the published literature.
Authors: Authors: Roberts RJ, Varmus HE, Ashburner M, Brown PO, Eisen MB, Khosla C, Kirschner M, Nusse R, Scott M, Wold B.
Science
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