Marc Kirschner, PhD

John Franklin Enders University Professor of Systems Biology, Harvard Medical School
Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length.
Authors: Authors: Liu S, Ginzberg MB, Patel N, Hild M, Leung B, Li Z, Chen YC, Chang N, Wang Y, Tan C, Diena S, Trimble W, Wasserman L, Jenkins JL, Kirschner MW, Kafri R.
Elife
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Hemichordate genomes and deuterostome origins.
Authors: Authors: Simakov O, Kawashima T, Marlétaz F, Jenkins J, Koyanagi R, Mitros T, Hisata K, Bredeson J, Shoguchi E, Gyoja F, Yue JX, Chen YC, Freeman RM, Sasaki A, Hikosaka-Katayama T, Sato A, Fujie M, Baughman KW, Levine J, Gonzalez P, Cameron C, Fritzenwanker JH, Pani AM, Goto H, Kanda M, Arakaki N, Yamasaki S, Qu J, Cree A, Ding Y, Dinh HH, Dugan S, Holder M, Jhangiani SN, Kovar CL, Lee SL, Lewis LR, Morton D, Nazareth LV, Okwuonu G, Santibanez J, Chen R, Richards S, Muzny DM, Gillis A, Peshkin L, Wu M, Humphreys T, Su YH, Putnam NH, Schmutz J, Fujiyama A, Yu JK, Tagawa K, Worley KC, Gibbs RA, Kirschner MW, Lowe CJ, Satoh N, Rokhsar DS, Gerhart J.
Nature
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APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.
Authors: Authors: Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W.
Dev Cell
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Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster.
Authors: Authors: Wühr M, Haas W, McAlister GC, Peshkin L, Rad R, Kirschner MW, Gygi SP.
Anal Chem
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Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression.
Authors: Authors: Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW, Rice JC.
Genes Dev
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Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.
Authors: Authors: Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N, Wei W.
Mol Biol Cell
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Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.
Authors: Authors: Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW.
Chem Biol
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Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.
Authors: Authors: Rape M, Kirschner MW.
Nature
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Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.
Authors: Authors: Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW.
Cell
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Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation.
Authors: Authors: Davis RL, Turner DL, Evans LM, Kirschner MW.
Dev Cell
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