Marc Kirschner, PhD
John Franklin Enders University Professor of Systems Biology, Harvard Medical School
A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis.
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly.
Authors: Authors: Campellone KG, Rankin S, Pawson T, Kirschner MW, Tipper DJ, Leong JM.
J Cell Biol
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J Cell Biol
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Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.
Authors: Authors: Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW.
Nature
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Nature
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Pin1 acts catalytically to promote a conformational change in Cdc25.
Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.
The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.
Authors: Authors: Shen M, Stukenberg PT, Kirschner MW, Lu KP.
Genes Dev
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Genes Dev
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Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation.
Authors: Authors: Lustig KD, Kroll KL, Sun EE, Kirschner MW.
Development
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Development
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The role of microtubules in growth cone turning at substrate boundaries.
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.
Authors: Authors: Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW.
Cell
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Cell
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An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes.