Michael Springer, PhD

Associate Professor of Systems Biology, Harvard Medical School
A distal, high-affinity binding site on the cyclin-CDK substrate Pho4 is important for its phosphorylation and regulation.
Authors: Authors: Byrne M, Miller N, Springer M, O'Shea EK.
J Mol Biol
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Polymorphisms in the yeast galactose sensor underlie a natural continuum of nutrient-decision phenotypes.
Authors: Authors: Lee KB, Wang J, Palme J, Escalante-Chong R, Hua B, Springer M.
PLoS Genet
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A chromatin-based mechanism for limiting divergent noncoding transcription.
Authors: Authors: Marquardt S, Escalante-Chong R, Pho N, Wang J, Churchman LS, Springer M, Buratowski S.
Cell
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Partially phosphorylated Pho4 activates transcription of a subset of phosphate-responsive genes.
Authors: Authors: Springer M, Wykoff DD, Miller N, O'Shea EK.
PLoS Biol
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Achieving global perfect homeostasis through transporter regulation.
Authors: Authors: Savir Y, Martynov A, Springer M.
PLoS Comput Biol
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SnapShot-Seq: a method for extracting genome-wide, in vivo mRNA dynamics from a single total RNA sample.
Authors: Authors: Gray JM, Harmin DA, Boswell SA, Cloonan N, Mullen TE, Ling JJ, Miller N, Kuersten S, Ma YC, McCarroll SA, Grimmond SM, Springer M.
PLoS One
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Viral discovery and sequence recovery using DNA microarrays.
Authors: Authors: Wang D, Urisman A, Liu YT, Springer M, Ksiazek TG, Erdman DD, Mardis ER, Hickenbotham M, Magrini V, Eldred J, Latreille JP, Wilson RK, Ganem D, DeRisi JL.
PLoS Biol
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Aneuploidy Causes Non-genetic Individuality.
Authors: Authors: Beach RR, Ricci-Tam C, Brennan CM, Moomau CA, Hsu PH, Hua B, Silberman RE, Springer M, Amon A.
Cell
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Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes.
Authors: Authors: Lim SC, Friemel M, Marum JE, Tucker EJ, Bruno DL, Riley LG, Christodoulou J, Kirk EP, Boneh A, DeGennaro CM, Springer M, Mootha VK, Rouault TA, Leimkühler S, Thorburn DR, Compton AG.
Hum Mol Genet
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Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis.
Authors: Authors: Boswell SA, Snavely A, Landry HM, Churchman LS, Gray JM, Springer M.
Nat Chem Biol
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