Michael Springer, PhD

Associate Professor of Systems Biology, Harvard Medical School
Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes.
Authors: Authors: Lim SC, Friemel M, Marum JE, Tucker EJ, Bruno DL, Riley LG, Christodoulou J, Kirk EP, Boneh A, DeGennaro CM, Springer M, Mootha VK, Rouault TA, Leimkühler S, Thorburn DR, Compton AG.
Hum Mol Genet
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Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis.
Authors: Authors: Boswell SA, Snavely A, Landry HM, Churchman LS, Gray JM, Springer M.
Nat Chem Biol
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Profiling of ubiquitin-like modifications reveals features of mitotic control.
Authors: Authors: Merbl Y, Refour P, Patel H, Springer M, Kirschner MW.
Cell
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Mutation effects predicted from sequence co-variation.
Authors: Authors: Hopf TA, Ingraham JB, Poelwijk FJ, Schärfe CP, Springer M, Sander C, Marks DS.
Nat Biotechnol
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Expression divergence measured by transcriptome sequencing of four yeast species.
Authors: Authors: Busby MA, Gray JM, Costa AM, Stewart C, Stromberg MP, Barnett D, Chuang JH, Springer M, Marth GT.
BMC Genomics
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Probabilistic adaptation in changing microbial environments.
Authors: Authors: Katz Y, Springer M.
PeerJ
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A general lack of compensation for gene dosage in yeast.
Authors: Authors: Springer M, Weissman JS, Kirschner MW.
Mol Syst Biol
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A competitive trade-off limits the selective advantage of increased antibiotic production.
Authors: Authors: Gerardin Y, Springer M, Kishony R.
Nat Microbiol
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Need-based up-regulation of protein levels in response to deletion of their duplicate genes.
Authors: Authors: DeLuna A, Springer M, Kirschner MW, Kishony R.
PLoS Biol
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Identifying Metabolic Subpopulations from Population Level Mass Spectrometry.
Authors: Authors: DeGennaro CM, Savir Y, Springer M.
PLoS One
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