Peter Sorger, PhD

Otto Krayer Professor of Systems Pharmacology, Harvard Medical School
Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.
Authors: Authors: Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, Sorger PK.
Cell Syst
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Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.
Authors: Authors: Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC.
Cell Rep
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Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.
Authors: Authors: Tan L, Gurbani D, Weisberg EL, Jones DS, Rao S, Singer WD, Bernard FM, Mowafy S, Jenney A, Du G, Nonami A, Griffin JD, Lauffenburger DA, Westover KD, Sorger PK, Gray NS.
Bioorg Med Chem
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Analysis of growth factor signaling in genetically diverse breast cancer lines.
Authors: Authors: Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Muhlich JL, Schoeberl B, Sorger PK.
BMC Biol
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An expanding role for cell biologists in drug discovery and pharmacology.
Authors: Authors: Sorger PK, Schoeberl B.
Mol Biol Cell
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Mps1 at kinetochores is essential for female mouse meiosis I.
Authors: Authors: Hached K, Xie SZ, Buffin E, Cladière D, Rachez C, Sacras M, Sorger PK, Wassmann K.
Development
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Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.
Authors: Authors: Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK.
Mol Syst Biol
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Crystal structure of the yeast inner kinetochore subunit Cep3p.
Authors: Authors: Bellizzi JJ, Sorger PK, Harrison SC.
Structure
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Analysis of kinesin motor function at budding yeast kinetochores.
Authors: Authors: Tytell JD, Sorger PK.
J Cell Biol
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Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data.
Authors: Authors: Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA.
J Comput Biol
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