Peter Sorger, PhD

Otto Krayer Professor of Systems Pharmacology, Harvard Medical School
Metrics other than potency reveal systematic variation in responses to cancer drugs.
Authors: Authors: Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, Sorger PK.
Nat Chem Biol
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Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis.
Authors: Authors: Gaudet S, Spencer SL, Chen WW, Sorger PK.
PLoS Comput Biol
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Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli.
Authors: Authors: Morris MK, Saez-Rodriguez J, Clarke DC, Sorger PK, Lauffenburger DA.
PLoS Comput Biol
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Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.
Authors: Authors: Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA.
Toxicol Appl Pharmacol
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Physicochemical modelling of cell signalling pathways.
Authors: Authors: Aldridge BB, Burke JM, Lauffenburger DA, Sorger PK.
Nat Cell Biol
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A compendium of signals and responses triggered by prodeath and prosurvival cytokines.
Authors: Authors: Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK.
Mol Cell Proteomics
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A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis.
Authors: Authors: Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB.
Mol Cell Proteomics
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Retention of the BUB3 checkpoint protein on lagging chromosomes.
Authors: Authors: Martinez-Exposito MJ, Kaplan KB, Copeland J, Sorger PK.
Proc Natl Acad Sci U S A
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Yeast heat shock factor contains separable transient and sustained response transcriptional activators.
Authors: Authors: Sorger PK.
Cell
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A single-cell landscape of high-grade serous ovarian cancer.
Authors: Authors: Izar B, Tirosh I, Stover EH, Wakiro I, Cuoco MS, Alter I, Rodman C, Leeson R, Su MJ, Shah P, Iwanicki M, Walker SR, Kanodia A, Melms JC, Mei S, Lin JR, Porter CBM, Slyper M, Waldman J, Jerby-Arnon L, Ashenberg O, Brinker TJ, Mills C, Rogava M, Vigneau S, Sorger PK, Garraway LA, Konstantinopoulos PA, Liu JF, Matulonis U, Johnson BE, Rozenblatt-Rosen O, Rotem A, Regev A.
Nat Med
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