Peter Sorger, PhD

Otto Krayer Professor of Systems Pharmacology, Harvard Medical School
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.
Authors: Authors: Jerby-Arnon L, Shah P, Cuoco MS, Rodman C, Su MJ, Melms JC, Leeson R, Kanodia A, Mei S, Lin JR, Wang S, Rabasha B, Liu D, Zhang G, Margolais C, Ashenberg O, Ott PA, Buchbinder EI, Haq R, Hodi FS, Boland GM, Sullivan RJ, Frederick DT, Miao B, Moll T, Flaherty KT, Herlyn M, Jenkins RW, Thummalapalli R, Kowalczyk MS, Cañadas I, Schilling B, Cartwright ANR, Luoma AM, Malu S, Hwu P, Bernatchez C, Forget MA, Barbie DA, Shalek AK, Tirosh I, Sorger PK, Wucherpfennig K, Van Allen EM, Schadendorf D, Johnson BE, Rotem A, Rozenblatt-Rosen O, Garraway LA, Yoon CH, Izar B, Regev A.
Cell
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Designing Drug-Response Experiments and Quantifying their Results.
Authors: Authors: Hafner M, Niepel M, Subramanian K, Sorger PK.
Curr Protoc Chem Biol
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Surviving apoptosis: life-death signaling in single cells.
Authors: Authors: Flusberg DA, Sorger PK.
Trends Cell Biol
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Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes.
Authors: Authors: Flusberg DA, Roux J, Spencer SL, Sorger PK.
Mol Biol Cell
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Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.
Authors: Authors: Aldridge BB, Gaudet S, Lauffenburger DA, Sorger PK.
Mol Syst Biol
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Dissecting variability in responses to cancer chemotherapy through systems pharmacology.
Authors: Authors: Yang R, Niepel M, Mitchison TK, Sorger PK.
Clin Pharmacol Ther
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Modeling a snap-action, variable-delay switch controlling extrinsic cell death.
Authors: Authors: Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK.
PLoS Biol
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Systems biology and combination therapy in the quest for clinical efficacy.
Authors: Authors: Fitzgerald JB, Schoeberl B, Nielsen UB, Sorger PK.
Nat Chem Biol
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A dual role for Bub1 in the spindle checkpoint and chromosome congression.
Authors: Authors: Meraldi P, Sorger PK.
EMBO J
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Bayesian network approach to cell signaling pathway modeling.
Authors: Authors: Sachs K, Gifford D, Jaakkola T, Sorger P, Lauffenburger DA.
Sci STKE
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