Peter Sorger, PhD

Otto Krayer Professor of Systems Pharmacology, Harvard Medical School
A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling.
Authors: Authors: Koch PD, Miller HR, Yu G, Tallarico JA, Sorger PK, Wang Y, Feng Y, Thomas JR, Ross NT, Mitchison T.
ACS Chem Biol
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Structure-guided development of covalent TAK1 inhibitors.
Authors: Authors: Tan L, Gurbani D, Weisberg EL, Hunter JC, Li L, Jones DS, Ficarro SB, Mowafy S, Tam CP, Rao S, Du G, Griffin JD, Sorger PK, Marto JA, Westover KD, Gray NS.
Bioorg Med Chem
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Failure analysis of clinical trials to test the amyloid hypothesis.
Authors: Authors: Hyman BT, Sorger P.
Ann Neurol
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Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
Authors: Authors: Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R.
Nat Commun
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Comparing signaling networks between normal and transformed hepatocytes using discrete logical models.
Authors: Authors: Saez-Rodriguez J, Alexopoulos LG, Zhang M, Morris MK, Lauffenburger DA, Sorger PK.
Cancer Res
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Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation.
Authors: Authors: Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA.
Mol Biosyst
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Flexible informatics for linking experimental data to mathematical models via DataRail.
Authors: Authors: Saez-Rodriguez J, Goldsipe A, Muhlich J, Alexopoulos LG, Millard B, Lauffenburger DA, Sorger PK.
Bioinformatics
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The response of human epithelial cells to TNF involves an inducible autocrine cascade.
Authors: Authors: Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK.
Cell
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Chromosome segregation and genomic stability.
Authors: Authors: Draviam VM, Xie S, Sorger PK.
Curr Opin Genet Dev
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Molecular analysis of kinetochore-microtubule attachment in budding yeast.
Authors: Authors: He X, Rines DR, Espelin CW, Sorger PK.
Cell
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