Peter Sorger, PhD

Otto Krayer Professor of Systems Pharmacology, Harvard Medical School
Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p.
Authors: Authors: Sassoon I, Severin FF, Andrews PD, Taba MR, Kaplan KB, Ashford AJ, Stark MJ, Sorger PK, Hyman AA.
Genes Dev
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Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation.
Authors: Authors: Sorger PK, Pelham HR.
Cell
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SARS-CoV-2 infection protects against rechallenge in rhesus macaques.
Authors: Authors: Chandrashekar A, Liu J, Martinot AJ, McMahan K, Mercado NB, Peter L, Tostanoski LH, Yu J, Maliga Z, Nekorchuk M, Busman-Sahay K, Terry M, Wrijil LM, Ducat S, Martinez DR, Atyeo C, Fischinger S, Burke JS, Slein MD, Pessaint L, Van Ry A, Greenhouse J, Taylor T, Blade K, Cook A, Finneyfrock B, Brown R, Teow E, Velasco J, Zahn R, Wegmann F, Abbink P, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kordana N, Li Z, Lifton MA, Mahrokhian SH, Maxfield LF, Nityanandam R, Nkolola JP, Schmidt AG, Miller AD, Baric RS, Alter G, Sorger PK, Estes JD, Andersen H, Lewis MG, Barouch DH.
Science
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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.
Authors: Authors: Chopra SS, Jenney A, Palmer A, Niepel M, Chung M, Mills C, Sivakumaren SC, Liu Q, Chen JY, Yapp C, Asara JM, Gray NS, Sorger PK.
Cell Syst
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Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade.
Authors: Authors: Dunn IF, Du Z, Touat M, Sisti MB, Wen PY, Umeton R, Dubuc AM, Ducar M, Canoll PD, Severson E, Elvin JA, Ramkissoon SH, Lin JR, Cabrera L, Acevedo B, Sorger PK, Ligon KL, Santagata S, Reardon DA.
JCO Precis Oncol
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Measuring Cancer Drug Sensitivity and Resistance in Cultured Cells.
Authors: Authors: Niepel M, Hafner M, Chung M, Sorger PK.
Curr Protoc Chem Biol
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Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold.
Authors: Authors: Roux J, Hafner M, Bandara S, Sims JJ, Hudson H, Chai D, Sorger PK.
Mol Syst Biol
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Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging.
Authors: Authors: Flusberg DA, Sorger PK.
Phys Biol
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Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
Authors: Authors: Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS.
J Biol Chem
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Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line.
Authors: Authors: Espelin CW, Goldsipe A, Sorger PK, Lauffenburger DA, de Graaf D, Hendriks BS.
Mol Biosyst
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