Peter Sorger, PhD

Otto Krayer Professor of Systems Pharmacology, Harvard Medical School
Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins.
Authors: Authors: Meraldi P, McAinsh AD, Rheinbay E, Sorger PK.
Genome Biol
View full abstract on Pubmed
Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast.
Authors: Authors: Gillett ES, Espelin CW, Sorger PK.
J Cell Biol
View full abstract on Pubmed
A role for the Adenomatous Polyposis Coli protein in chromosome segregation.
Authors: Authors: Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Näthke IS.
Nat Cell Biol
View full abstract on Pubmed
Two genes required for the binding of an essential Saccharomyces cerevisiae kinetochore complex to DNA.
Authors: Authors: Sorger PK, Doheny KF, Hieter P, Kopski KM, Huffaker TC, Hyman AA.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Response and mechanisms of resistance to larotrectinib and selitrectinib in metastatic undifferentiated sarcoma harboring oncogenic fusion of NTRK1.
Authors: Authors: Hemming ML, Nathenson MJ, Lin JR, Mei S, Du Z, Malik K, Marino-Enriquez A, Jagannathan JP, Sorger PK, Bertagnolli M, Sicinska E, Demetri GD, Santagata S.
JCO Precis Oncol
View full abstract on Pubmed
Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.
Authors: Authors: Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, Sorger PK.
Cell Syst
View full abstract on Pubmed
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.
Authors: Authors: Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC.
Cell Rep
View full abstract on Pubmed
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.
Authors: Authors: Tan L, Gurbani D, Weisberg EL, Jones DS, Rao S, Singer WD, Bernard FM, Mowafy S, Jenney A, Du G, Nonami A, Griffin JD, Lauffenburger DA, Westover KD, Sorger PK, Gray NS.
Bioorg Med Chem
View full abstract on Pubmed
Analysis of growth factor signaling in genetically diverse breast cancer lines.
Authors: Authors: Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Muhlich JL, Schoeberl B, Sorger PK.
BMC Biol
View full abstract on Pubmed
An expanding role for cell biologists in drug discovery and pharmacology.
Authors: Authors: Sorger PK, Schoeberl B.
Mol Biol Cell
View full abstract on Pubmed