Peter Sorger, PhD

Otto Krayer Professor of Systems Pharmacology, Harvard Medical School
Genetic selection of peptide inhibitors of biological pathways.
Authors: Authors: Norman TC, Smith DL, Sorger PK, Drees BL, O'Rourke SM, Hughes TR, Roberts CJ, Friend SH, Fields S, Murray AW.
Science
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Heat shock factor and the heat shock response.
Authors: Authors: Sorger PK.
Cell
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Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.
Authors: Authors: Zervantonakis IK, Poskus MD, Scott AL, Selfors LM, Lin JR, Dillon DA, Pathania S, Sorger PK, Mills GB, Brugge JS.
Proc Natl Acad Sci U S A
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Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity.
Authors: Authors: Melms JC, Vallabhaneni S, Mills CE, Yapp C, Chen JY, Morelli E, Waszyk P, Kumar S, Deming D, Moret N, Rodriguez S, Subramanian K, Rogava M, Cartwright ANR, Luoma A, Mei S, Brinker TJ, Miller DM, Spektor A, Schadendorf D, Riggi N, Wucherpfennig KW, Sorger PK, Izar B.
Cancer Res
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A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers.
Authors: Authors: Rao S, Du G, Hafner M, Subramanian K, Sorger PK, Gray NS.
J Biol Chem
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Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling.
Authors: Authors: Niepel M, Hafner M, Duan Q, Wang Z, Paull EO, Chung M, Lu X, Stuart JM, Golub TR, Subramanian A, Ma'ayan A, Sorger PK.
Nat Commun
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Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs.
Authors: Authors: Hafner M, Niepel M, Chung M, Sorger PK.
Nat Methods
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Metrics other than potency reveal systematic variation in responses to cancer drugs.
Authors: Authors: Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, Sorger PK.
Nat Chem Biol
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Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis.
Authors: Authors: Gaudet S, Spencer SL, Chen WW, Sorger PK.
PLoS Comput Biol
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Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli.
Authors: Authors: Morris MK, Saez-Rodriguez J, Clarke DC, Sorger PK, Lauffenburger DA.
PLoS Comput Biol
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