Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.
Authors: Authors: Miller MA, Mikula H, Luthria G, Li R, Kronister S, Prytyskach M, Kohler RH, Mitchison T, Weissleder R.
ACS Nano
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Vimentin fibers orient traction stress.
Authors: Authors: Costigliola N, Ding L, Burckhardt CJ, Han SJ, Gutierrez E, Mota A, Groisman A, Mitchison TJ, Danuser G.
Proc Natl Acad Sci U S A
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Erratum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.
Authors: Authors: Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ.
Nat Chem Biol
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MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.
Authors: Authors: Wang Y, Lee YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, Gray NS, Mitchison TJ, Zhao JJ.
Elife
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Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities.
Authors: Authors: Barkauskaite E, Brassington A, Tan ES, Warwicker J, Dunstan MS, Banos B, Lafite P, Ahel M, Mitchison TJ, Ahel I, Leys D.
Nat Commun
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Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.
Authors: Authors: Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ.
Cancer Res
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Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules.
Authors: Authors: Needleman DJ, Groen A, Ohi R, Maresca T, Mirny L, Mitchison T.
Mol Biol Cell
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Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules.
Authors: Authors: Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED.
Curr Biol
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Polar stimulation and constrained cell migration in microfluidic channels.
Authors: Authors: Irimia D, Charras G, Agrawal N, Mitchison T, Toner M.
Lab Chip
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Small molecules in an RNAi world.
Authors: Authors: Eggert US, Field CM, Mitchison TJ.
Mol Biosyst
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