Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Disassembly of Actin and Keratin Networks by Aurora B Kinase at the Midplane of Cleaving Xenopus laevis Eggs.
Authors: Authors: Field CM, Pelletier JF, Mitchison TJ.
Curr Biol
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Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.
Authors: Authors: Wang Y, Li YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, Gray NS, Mitchison TJ, Zhao JJ.
Elife
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Amyloid-like Self-Assembly of a Cellular Compartment.
Authors: Authors: Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ.
Cell
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Microtubule nucleation remote from centrosomes may explain how asters span large cells.
Authors: Authors: Ishihara K, Nguyen PA, Groen AC, Field CM, Mitchison TJ.
Proc Natl Acad Sci U S A
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Micron-scale coherence in interphase chromatin dynamics.
Authors: Authors: Zidovska A, Weitz DA, Mitchison TJ.
Proc Natl Acad Sci U S A
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Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis.
Authors: Authors: Hu CK, Ozlü N, Coughlin M, Steen JJ, Mitchison TJ.
Mol Biol Cell
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Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest.
Authors: Authors: Huang HC, Mitchison TJ, Shi J.
PLoS One
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Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds.
Authors: Authors: Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA.
Nat Rev Drug Discov
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Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.
Authors: Authors: Shi J, Orth JD, Mitchison T.
Cancer Res
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Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1.
Authors: Authors: Brieher WM, Kueh HY, Ballif BA, Mitchison TJ.
J Cell Biol
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