Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Assembly of Spindles and Asters in Xenopus Egg Extracts.
Authors: Authors: Field CM, Mitchison TJ.
Cold Spring Harb Protoc
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Physical basis of large microtubule aster growth.
Authors: Authors: Ishihara K, Korolev KS, Mitchison TJ.
Elife
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Extracellular poly(ADP-ribose) is a pro-inflammatory signal for macrophages.
Authors: Authors: Krukenberg KA, Kim S, Tan ES, Maliga Z, Mitchison TJ.
Chem Biol
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Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments.
Authors: Authors: Prentice-Mott HV, Chang CH, Mahadevan L, Mitchison TJ, Irimia D, Shah JV.
Proc Natl Acad Sci U S A
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Vascular disrupting agent drug classes differ in effects on the cytoskeleton.
Authors: Authors: Kim S, Peshkin L, Mitchison TJ.
PLoS One
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KIF4 regulates midzone length during cytokinesis.
Authors: Authors: Hu CK, Coughlin M, Field CM, Mitchison TJ.
Curr Biol
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Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly.
Authors: Authors: Chang P, Coughlin M, Mitchison TJ.
Mol Biol Cell
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Mitosis: new roles for myosin-X and actin at the spindle.
Authors: Authors: Wühr M, Mitchison TJ, Field CM.
Curr Biol
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Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization.
Authors: Authors: Li J, Brieher WM, Scimone ML, Kang SJ, Zhu H, Yin H, von Andrian UH, Mitchison T, Yuan J.
Nat Cell Biol
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A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes.
Authors: Authors: Dorer RK, Zhong S, Tallarico JA, Wong WH, Mitchison TJ, Murray AW.
Curr Biol
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