Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked.
Authors: Authors: Shirasu-Hiza M, Perlman ZE, Wittmann T, Karsenti E, Mitchison TJ.
Curr Biol
View full abstract on Pubmed
A novel action of histone deacetylase inhibitors in a protein aggresome disease model.
Authors: Authors: Corcoran LJ, Mitchison TJ, Liu Q.
Curr Biol
View full abstract on Pubmed
Dynamics of the mitotic spindle--potential therapeutic targets.
Authors: Authors: Miyamoto DT, Perlman ZE, Mitchison TJ, Shirasu-Hiza M.
Prog Cell Cycle Res
View full abstract on Pubmed
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.
Authors: Authors: Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J.
Nat Cell Biol
View full abstract on Pubmed
The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro.
Authors: Authors: Desai A, Murray A, Mitchison TJ, Walczak CE.
Methods Cell Biol
View full abstract on Pubmed
Rappaport rules: cleavage furrow induction in animal cells.
Authors: Authors: Oegema K, Mitchison TJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Myosin is involved in postmitotic cell spreading.
Authors: Authors: Cramer LP, Mitchison TJ.
J Cell Biol
View full abstract on Pubmed
Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts.
Authors: Authors: Hirano T, Mitchison TJ.
J Cell Biol
View full abstract on Pubmed
Control of actin polymerization in live and permeabilized fibroblasts.
Authors: Authors: Symons MH, Mitchison TJ.
J Cell Biol
View full abstract on Pubmed
Cell division. Kinetochores on the move.
Authors: Authors: Mitchison T, Hyman A.
Nature
View full abstract on Pubmed