Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Isolation of mammalian centrosomes.
Authors: Authors: Mitchison TJ, Kirschner MW.
Methods Enzymol
View full abstract on Pubmed
A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line.
Authors: Authors: Song Y, Subramanian K, Berberich MJ, Rodriguez S, Latorre IJ, Luria CM, Everley R, Albers MW, Mitchison TJ, Sorger PK.
Sci Data
View full abstract on Pubmed
Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug?
Authors: Authors: Mitchison TJ, Pineda J, Shi J, Florian S.
Open Biol
View full abstract on Pubmed
Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis.
Authors: Authors: Son S, Kang JH, Oh S, Kirschner MW, Mitchison TJ, Manalis S.
J Cell Biol
View full abstract on Pubmed
Organization of early frog embryos by chemical waves emanating from centrosomes.
Authors: Authors: Ishihara K, Nguyen PA, Wühr M, Groen AC, Field CM, Mitchison TJ.
Philos Trans R Soc Lond B Biol Sci
View full abstract on Pubmed
Maintenance of mitochondrial oxygen homeostasis by cosubstrate compensation.
Authors: Authors: Kueh HY, Niethammer P, Mitchison TJ.
Biophys J
View full abstract on Pubmed
Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen.
Authors: Authors: Kwiatkowski N, Deng X, Wang J, Tan L, Villa F, Santaguida S, Huang HC, Mitchison T, Musacchio A, Gray N.
ACS Chem Biol
View full abstract on Pubmed
FRET measurements of kinesin neck orientation reveal a structural basis for processivity and asymmetry.
Authors: Authors: Martin DS, Fathi R, Mitchison TJ, Gelles J.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Size and speed go hand in hand in cytokinesis.
Authors: Authors: Wühr M, Mitchison TJ, Field CM.
Cell
View full abstract on Pubmed
Integrating high-content screening and ligand-target prediction to identify mechanism of action.
Authors: Authors: Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y.
Nat Chem Biol
View full abstract on Pubmed