Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes.
Authors: Authors: Karsenti E, Kobayashi S, Mitchison T, Kirschner M.
J Cell Biol
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Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.
Authors: Authors: Liu L, Su X, Quinn WJ, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD.
Cell Metab
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The balbiani body and the concept of physiological amyloids.
Authors: Authors: Boke E, Mitchison TJ.
Cell Cycle
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Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins.
Authors: Authors: Nguyen PA, Field CM, Groen AC, Mitchison TJ, Loose M.
Methods Cell Biol
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The bacterial cell division proteins FtsA and FtsZ self-organize into dynamic cytoskeletal patterns.
Authors: Authors: Loose M, Mitchison TJ.
Nat Cell Biol
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Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI.
Authors: Authors: Zhang X, Wang W, Bedigian AV, Coughlin ML, Mitchison TJ, Eggert US.
Proc Natl Acad Sci U S A
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Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL.
Authors: Authors: Shi J, Zhou Y, Huang HC, Mitchison TJ.
Cancer Res
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Force and length in the mitotic spindle.
Authors: Authors: Dumont S, Mitchison TJ.
Curr Biol
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Evidence for an upper limit to mitotic spindle length.
Authors: Authors: Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ.
Curr Biol
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Meiotic spindle: sculpted by severing.
Authors: Authors: Ribbeck K, Mitchison TJ.
Curr Biol
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