Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes.
Authors: Authors: Dorer RK, Zhong S, Tallarico JA, Wong WH, Mitchison TJ, Murray AW.
Curr Biol
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A standardized kinesin nomenclature.
Authors: Authors: Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L.
J Cell Biol
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The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides.
Authors: Authors: Vrabioiu AM, Gerber SA, Gygi SP, Field CM, Mitchison TJ.
J Biol Chem
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EB1 targets to kinetochores with attached, polymerizing microtubules.
Authors: Authors: Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ.
Mol Biol Cell
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Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis.
Authors: Authors: Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL.
Chem Biol
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A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity.
Authors: Authors: Walczak CE, Vernos I, Mitchison TJ, Karsenti E, Heald R.
Curr Biol
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Actin dynamics in vivo.
Authors: Authors: Welch MD, Mallavarapu A, Rosenblatt J, Mitchison TJ.
Curr Opin Cell Biol
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The bulk of unpolymerized actin in Xenopus egg extracts is ATP-bound.
Authors: Authors: Rosenblatt J, Peluso P, Mitchison TJ.
Mol Biol Cell
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Mitotic spindle organization by a plus-end-directed microtubule motor.
Authors: Authors: Sawin KE, LeGuellec K, Philippe M, Mitchison TJ.
Nature
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Poleward microtubule flux mitotic spindles assembled in vitro.
Authors: Authors: Sawin KE, Mitchison TJ.
J Cell Biol
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