Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability.
Authors: Authors: Mitchison TJ, Kirschner MW.
Cell Biophys
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Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material.
Authors: Authors: Calarco-Gillam PD, Siebert MC, Hubble R, Mitchison T, Kirschner M.
Cell
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Labeling Carboxyl Groups of Surface-Exposed Proteins Provides an Orthogonal Approach for Cell Surface Isolation.
Authors: Authors: Özkan Küçük NE, Sanal E, Tan E, Mitchison T, Özlü N.
J Proteome Res
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Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response.
Authors: Authors: Giedt RJ, Fumene Feruglio P, Pathania D, Yang KS, Kilcoyne A, Vinegoni C, Mitchison TJ, Weissleder R.
Sci Rep
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Corrigendum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.
Authors: Authors: Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ.
Nat Chem Biol
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Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts.
Authors: Authors: Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA.
J Cell Biol
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Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers.
Authors: Authors: Tan ES, Krukenberg KA, Mitchison TJ.
Anal Biochem
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Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes.
Authors: Authors: Brangwynne CP, Mitchison TJ, Hyman AA.
Proc Natl Acad Sci U S A
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Structural plasticity in actin and tubulin polymer dynamics.
Authors: Authors: Kueh HY, Mitchison TJ.
Science
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Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers.
Authors: Authors: Kueh HY, Charras GT, Mitchison TJ, Brieher WM.
J Cell Biol
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