Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

A model for cleavage plane determination in early amphibian and fish embryos.
Authors: Authors: Wühr M, Tan ES, Parker SK, Detrich HW, Mitchison TJ.
Curr Biol
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Compression regulates mitotic spindle length by a mechanochemical switch at the poles.
Authors: Authors: Dumont S, Mitchison TJ.
Curr Biol
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Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm.
Authors: Authors: Niethammer P, Kueh HY, Mitchison TJ.
Curr Biol
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Microtubule dynamic instability.
Authors: Authors: Burbank KS, Mitchison TJ.
Curr Biol
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High-content screening and profiling of drug activity in an automated centrosome-duplication assay.
Authors: Authors: Perlman ZE, Mitchison TJ, Mayer TU.
Chembiochem
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Synthesis and phenotypic screening of a Guanine-mimetic library.
Authors: Authors: Miller SC, Mitchison TJ.
Chembiochem
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Rapid de-localization of actin leading edge components with BDM treatment.
Authors: Authors: Yarrow JC, Lechler T, Li R, Mitchison TJ.
BMC Cell Biol
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Single-molecule speckle analysis of actin filament turnover in lamellipodia.
Authors: Authors: Watanabe N, Mitchison TJ.
Science
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Regulated actin cytoskeleton assembly at filopodium tips controls their extension and retraction.
Authors: Authors: Mallavarapu A, Mitchison T.
J Cell Biol
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Purification and assay of gamma tubulin ring complex.
Authors: Authors: Zheng Y, Wong ML, Alberts B, Mitchison T.
Methods Enzymol
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