Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts.
Authors: Authors: Theriot JA, Rosenblatt J, Portnoy DA, Goldschmidt-Clermont PJ, Mitchison TJ.
Cell
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The nucleation-release model of actin filament dynamics in cell motility.
Authors: Authors: Theriot JA, Mitchison TJ.
Trends Cell Biol
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Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts.
Authors: Authors: Belmont LD, Hyman AA, Sawin KE, Mitchison TJ.
Cell
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Beyond self-assembly: from microtubules to morphogenesis.
Authors: Authors: Kirschner M, Mitchison T.
Cell
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Analysis of the sites of integration of viral DNA sequences in rat cells transformed by adenovirus 2 or SV40.
Authors: Authors: Sambrook J, Greene R, Stringer J, Mitchison T, Hu SL, Botchan M.
Cold Spring Harb Symp Quant Biol
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Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues.
Authors: Authors: Gasic I, Boswell SA, Mitchison TJ.
PLoS Biol
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Spindle-to-Cortex Communication in Cleaving Frog Eggs.
Authors: Authors: Mitchison TJ, Field CM.
Cold Spring Harb Symp Quant Biol
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Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells.
Authors: Authors: Al-Obaidi N, Mitchison TJ, Crews CM, Mayer TU.
ACS Chem Biol
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Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.
Authors: Authors: Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ.
Nat Chem Biol
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Anticancer flavonoids are mouse-selective STING agonists.
Authors: Authors: Kim S, Li L, Maliga Z, Yin Q, Wu H, Mitchison TJ.
ACS Chem Biol
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