Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work.
Authors: Authors: Waters JC, Mitchison TJ, Rieder CL, Salmon ED.
Mol Biol Cell
View full abstract on Pubmed
Towards a pharmacological genetics.
Authors: Authors: Mitchison TJ.
Chem Biol
View full abstract on Pubmed
A GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts.
Authors: Authors: Symons MH, Mitchison TJ.
J Cell Biol
View full abstract on Pubmed
Mitosis. The kinetochore in captivity.
Authors: Authors: Mitchison TJ.
Nature
View full abstract on Pubmed
Sites of microtubule assembly and disassembly in the mitotic spindle.
Authors: Authors: Mitchison T, Evans L, Schulze E, Kirschner M.
Cell
View full abstract on Pubmed
Integration and excision of SV40 DNA from the chromosome of a transformed cell.
Authors: Authors: Botchan M, Stringer J, Mitchison T, Sambrook J.
Cell
View full abstract on Pubmed
A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor.
Authors: Authors: Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Genetic disease in India and the West compared: provisional analysis of population dynamics.
Authors: Authors: Mitchison N, Mitchison T.
J Genet
View full abstract on Pubmed
Xenopus extract approaches to studying microtubule organization and signaling in cytokinesis.
Authors: Authors: Field CM, Pelletier JF, Mitchison TJ.
Methods Cell Biol
View full abstract on Pubmed
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin.
Authors: Authors: Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R.
Sci Transl Med
View full abstract on Pubmed