Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Organization of early frog embryos by chemical waves emanating from centrosomes.
Authors: Authors: Ishihara K, Nguyen PA, Wühr M, Groen AC, Field CM, Mitchison TJ.
Philos Trans R Soc Lond B Biol Sci
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Maintenance of mitochondrial oxygen homeostasis by cosubstrate compensation.
Authors: Authors: Kueh HY, Niethammer P, Mitchison TJ.
Biophys J
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Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen.
Authors: Authors: Kwiatkowski N, Deng X, Wang J, Tan L, Villa F, Santaguida S, Huang HC, Mitchison T, Musacchio A, Gray N.
ACS Chem Biol
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FRET measurements of kinesin neck orientation reveal a structural basis for processivity and asymmetry.
Authors: Authors: Martin DS, Fathi R, Mitchison TJ, Gelles J.
Proc Natl Acad Sci U S A
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Size and speed go hand in hand in cytokinesis.
Authors: Authors: Wühr M, Mitchison TJ, Field CM.
Cell
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Integrating high-content screening and ligand-target prediction to identify mechanism of action.
Authors: Authors: Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y.
Nat Chem Biol
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Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol.
Authors: Authors: Maliga Z, Mitchison TJ.
BMC Chem Biol
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Poly(ADP-ribose) is required for spindle assembly and structure.
Authors: Authors: Chang P, Jacobson MK, Mitchison TJ.
Nature
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A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii.
Authors: Authors: Carey KL, Westwood NJ, Mitchison TJ, Ward GE.
Proc Natl Acad Sci U S A
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Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification.
Authors: Authors: Shirasu-Hiza M, Coughlin P, Mitchison T.
J Cell Biol
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