Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL.
Authors: Authors: Shi J, Zhou Y, Huang HC, Mitchison TJ.
Cancer Res
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Force and length in the mitotic spindle.
Authors: Authors: Dumont S, Mitchison TJ.
Curr Biol
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Evidence for an upper limit to mitotic spindle length.
Authors: Authors: Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ.
Curr Biol
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Meiotic spindle: sculpted by severing.
Authors: Authors: Ribbeck K, Mitchison TJ.
Curr Biol
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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
Authors: Authors: Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J.
Nat Chem Biol
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Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.
Authors: Authors: Eggert US, Kiger AA, Richter C, Perlman ZE, Perrimon N, Mitchison TJ, Field CM.
PLoS Biol
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Determining the position of the cell division plane.
Authors: Authors: Canman JC, Cameron LA, Maddox PS, Straight A, Tirnauer JS, Mitchison TJ, Fang G, Kapoor TM, Salmon ED.
Nature
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Cytoskeleton: what does GTP do for septins?
Authors: Authors: Mitchison TJ, Field CM.
Curr Biol
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Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP.
Authors: Authors: Taunton J, Rowning BA, Coughlin ML, Wu M, Moon RT, Mitchison TJ, Larabell CA.
J Cell Biol
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Tubulin and FtsZ structures: functional and therapeutic implications.
Authors: Authors: Desai A, Mitchison TJ.
Bioessays
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