Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Exo1: a new chemical inhibitor of the exocytic pathway.
Authors: Authors: Feng Y, Yu S, Lasell TK, Jadhav AP, Macia E, Chardin P, Melancon P, Roth M, Mitchison T, Kirchhausen T.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Probing cell division with "chemical genetics".
Authors: Authors: Mitchison TJ.
Harvey Lect
View full abstract on Pubmed
Spatial control of actin polymerization during neutrophil chemotaxis.
Authors: Authors: Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR.
Nat Cell Biol
View full abstract on Pubmed
Purification of cytoskeletal proteins using peptide antibodies.
Authors: Authors: Field CM, Oegema K, Zheng Y, Mitchison TJ, Walczak CE.
Methods Enzymol
View full abstract on Pubmed
Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules.
Authors: Authors: Belmont LD, Mitchison TJ.
Cell
View full abstract on Pubmed
Mitosis. Kinetochores pass the IQ test.
Authors: Authors: Murray AW, Mitchison TJ.
Curr Biol
View full abstract on Pubmed
Evidence for kinesin-related proteins in the mitotic apparatus using peptide antibodies.
Authors: Authors: Sawin KE, Mitchison TJ, Wordeman LG.
J Cell Sci
View full abstract on Pubmed
Tubulin flux in the mitotic spindle: where does it come from, where is it going?
Authors: Authors: Mitchison TJ, Sawin KE.
Cell Motil Cytoskeleton
View full abstract on Pubmed
Isolation of mammalian centrosomes.
Authors: Authors: Mitchison TJ, Kirschner MW.
Methods Enzymol
View full abstract on Pubmed
Unsupervised identification of disease states from high-dimensional physiological and histopathological profiles.
Authors: Authors: Shimada K, Mitchison TJ.
Mol Syst Biol
View full abstract on Pubmed