Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Symmetry of septin hourglass and ring structures.
Authors: Authors: Vrabioiu AM, Mitchison TJ.
J Mol Biol
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Towards an understanding of yeast septins' organization in vivo.
Authors: Authors: Vrabioiu A, Mitchison T.
Microsc Microanal
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Mechanical properties of Xenopus egg cytoplasmic extracts.
Authors: Authors: Valentine MT, Perlman ZE, Mitchison TJ, Weitz DA.
Biophys J
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Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division.
Authors: Authors: Romberg L, Mitchison TJ.
Biochemistry
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Self- and actin-templated assembly of Mammalian septins.
Authors: Authors: Kinoshita M, Field CM, Coughlin ML, Straight AF, Mitchison TJ.
Dev Cell
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Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.
Authors: Authors: Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ.
J Cell Biol
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An efficient substitution reaction for the preparation of thyroid hormone analogues.
Authors: Authors: Yoshihara HA, Chiellini G, Mitchison TJ, Scanlan TS.
Bioorg Med Chem
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Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails.
Authors: Authors: Rosenblatt J, Agnew BJ, Abe H, Bamburg JR, Mitchison TJ.
J Cell Biol
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The SMC family: from chromosome condensation to dosage compensation.
Authors: Authors: Hirano T, Mitchison TJ, Swedlow JR.
Curr Opin Cell Biol
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Compare and contrast actin filaments and microtubules.
Authors: Authors: Mitchison TJ.
Mol Biol Cell
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