Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Bipolarization and poleward flux correlate during Xenopus extract spindle assembly.
Authors: Authors: Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM.
Mol Biol Cell
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Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics.
Authors: Authors: Maddox P, Straight A, Coughlin P, Mitchison TJ, Salmon ED.
J Cell Biol
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The microtubule-destabilizing kinesin XKCM1 is required for chromosome positioning during spindle assembly.
Authors: Authors: Walczak CE, Gan EC, Desai A, Mitchison TJ, Kline-Smith SL.
Curr Biol
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Molecular "vitalism".
Authors: Authors: Kirschner M, Gerhart J, Mitchison T.
Cell
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Actin, cofilin and cognition.
Authors: Authors: Rosenblatt J, Mitchison TJ.
Nature
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Microtubule polymerization dynamics.
Authors: Authors: Desai A, Mitchison TJ.
Annu Rev Cell Dev Biol
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Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis.
Authors: Authors: Wordeman L, Mitchison TJ.
J Cell Biol
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Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.
Authors: Authors: Hyman AA, Salser S, Drechsel DN, Unwin N, Mitchison TJ.
Mol Biol Cell
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Regulation of the direction of chromosome movement.
Authors: Authors: Hyman AA, Mitchison TJ.
Cold Spring Harb Symp Quant Biol
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Cell motility: good things from slime.
Authors: Authors: Mitchison TJ.
Nature
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