Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization.
Authors: Authors: Theriot JA, Mitchison TJ, Tilney LG, Portnoy DA.
Nature
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Cell biology. Motoring in the spindle.
Authors: Authors: Sawin K, Mitchison T.
Nature
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Direct observation of steady-state microtubule dynamics.
Authors: Authors: Kristofferson D, Mitchison T, Kirschner M.
J Cell Biol
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Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.
Authors: Authors: Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ.
Elife
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Prc1E and Kif4A control microtubule organization within and between large Xenopus egg asters.
Authors: Authors: Nguyen PA, Field CM, Mitchison TJ.
Mol Biol Cell
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Purification and Fluorescent Labeling of Tubulin from Xenopus laevis Egg Extracts.
Authors: Authors: Groen AC, Mitchison TJ.
Methods Mol Biol
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Spatial organization of cytokinesis signaling reconstituted in a cell-free system.
Authors: Authors: Nguyen PA, Groen AC, Loose M, Ishihara K, Wühr M, Field CM, Mitchison TJ.
Science
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Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells.
Authors: Authors: Choi PJ, Mitchison TJ.
Proc Natl Acad Sci U S A
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The proliferation rate paradox in antimitotic chemotherapy.
Authors: Authors: Mitchison TJ.
Mol Biol Cell
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Quantitative analysis of actin turnover in Listeria comet tails: evidence for catastrophic filament turnover.
Authors: Authors: Kueh HY, Brieher WM, Mitchison TJ.
Biophys J
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