Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Localization of antigenic determinants in whole Drosophila embryos.
Authors: Authors: Mitchison TJ, Sedat J.
Dev Biol
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A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling.
Authors: Authors: Koch PD, Miller HR, Yu G, Tallarico JA, Sorger PK, Wang Y, Feng Y, Thomas JR, Ross NT, Mitchison T.
ACS Chem Biol
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Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.
Authors: Authors: Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ.
Proc Natl Acad Sci U S A
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Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis.
Authors: Authors: Özlü N, Qureshi MH, Toyoda Y, Renard BY, Mollaoglu G, Özkan NE, Bulbul S, Poser I, Timm W, Hyman AA, Mitchison TJ, Steen JA.
EMBO J
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A question of taste.
Authors: Authors: Mitchison TJ.
Mol Biol Cell
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Deformations within moving kinetochores reveal different sites of active and passive force generation.
Authors: Authors: Dumont S, Salmon ED, Mitchison TJ.
Science
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Live imaging of the cytoskeleton in early cleavage-stage zebrafish embryos.
Authors: Authors: Wühr M, Obholzer ND, Megason SG, Detrich HW, Mitchison TJ.
Methods Cell Biol
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Animal cell hydraulics.
Authors: Authors: Charras GT, Mitchison TJ, Mahadevan L.
J Cell Sci
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A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly.
Authors: Authors: Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ.
J Cell Sci
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Reassembly of contractile actin cortex in cell blebs.
Authors: Authors: Charras GT, Hu CK, Coughlin M, Mitchison TJ.
J Cell Biol
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