Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.
Authors: Authors: Shi J, Orth JD, Mitchison T.
Cancer Res
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Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1.
Authors: Authors: Brieher WM, Kueh HY, Ballif BA, Mitchison TJ.
J Cell Biol
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Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles.
Authors: Authors: Mitchison TJ, Maddox P, Gaetz J, Groen A, Shirasu M, Desai A, Salmon ED, Kapoor TM.
Mol Biol Cell
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Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis.
Authors: Authors: Salic A, Waters JC, Mitchison TJ.
Cell
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Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.
Authors: Authors: Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, Takuwa Y, Sugimoto N, Mitchison T, Bourne HR.
Cell
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Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos.
Authors: Authors: Maddox P, Desai A, Oegema K, Mitchison TJ, Salmon ED.
Curr Biol
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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.
Authors: Authors: Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ.
Science
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Purification and assay of the platelet Arp2/3 complex.
Authors: Authors: Welch MD, Mitchison TJ.
Methods Enzymol
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The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work.
Authors: Authors: Waters JC, Mitchison TJ, Rieder CL, Salmon ED.
Mol Biol Cell
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Towards a pharmacological genetics.
Authors: Authors: Mitchison TJ.
Chem Biol
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