Wade Harper, Ph.D.

Bert and Natalie Vallee Professor of Molecular Pathology, Harvard Medical School
RING finger specificity in SCF-driven protein destruction.
Authors: Authors: Jin J, Harper JW.
Dev Cell
View full abstract on Pubmed
Skipping into the E2F1-destruction pathway.
Authors: Authors: Harper JW, Elledge SJ.
Nat Cell Biol
View full abstract on Pubmed
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Authors: Authors: Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ.
Cell
View full abstract on Pubmed
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Authors: Authors: Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP.
Nature
View full abstract on Pubmed
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
Authors: Authors: Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW.
Science
View full abstract on Pubmed
Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4.
Authors: Authors: Leng X, Noble M, Adams PD, Qin J, Harper JW.
Mol Cell Biol
View full abstract on Pubmed
Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.
Authors: Authors: Skowyra D, Koepp DM, Kamura T, Conrad MN, Conaway RC, Conaway JW, Elledge SJ, Harper JW.
Science
View full abstract on Pubmed
A phosphorylation-driven ubiquitination switch for cell-cycle control.
Authors: Authors: Harper JW.
Trends Cell Biol
View full abstract on Pubmed
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.
Authors: Authors: Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW.
Genes Dev
View full abstract on Pubmed
The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente.
Authors: Authors: Dikic I, Harper W, Hay R, Langer T, Rape M, Sixma T, Walczak H.
EMBO Rep
View full abstract on Pubmed