Wade Harper, Ph.D.
Bert and Natalie Vallee Professor of Molecular Pathology, Harvard Medical School
The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.
Culprits in the degradation of cyclin E apprehended.
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
Authors: Authors: Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ.
Cell
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Cell
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Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
Authors: Authors: Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ.
Cell
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Cell
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A family of mammalian F-box proteins.
Authors: Authors: Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW.
Curr Biol
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Curr Biol
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Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition.
Authors: Authors: Passmore LA, McCormack EA, Au SW, Paul A, Willison KR, Harper JW, Barford D.
EMBO J
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EMBO J
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Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E.
Authors: Authors: Wang Y, Penfold S, Tang X, Hattori N, Riley P, Harper JW, Cross JC, Tyers M.
Curr Biol
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Curr Biol
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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.
Authors: Authors: Deng C, Zhang P, Harper JW, Elledge SJ, Leder P.
Cell
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Cell
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The anaphase-promoting complex: it's not just for mitosis any more.