Wade Harper, Ph.D.

Bert and Natalie Vallee Professor of Molecular Pathology, Harvard Medical School
617-432-6590
A phosphorylation-driven ubiquitination switch for cell-cycle control.
Authors: Authors: Harper JW.
Trends Cell Biol
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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.
Authors: Authors: Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW.
Genes Dev
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The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente.
Authors: Authors: Dikic I, Harper W, Hay R, Langer T, Rape M, Sixma T, Walczak H.
EMBO Rep
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Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.
Authors: Authors: Au SW, Leng X, Harper JW, Barford D.
J Mol Biol
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Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication.
Authors: Authors: Ma T, Zou N, Lin BY, Chow LT, Harper JW.
Proc Natl Acad Sci U S A
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Understanding cullin-RING E3 biology through proteomics-based substrate identification.
Authors: Authors: Harper JW, Tan MK.
Mol Cell Proteomics
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Analysis of acetic acid-induced whitening of high-grade squamous intraepithelial lesions.
Authors: Authors: Pogue BW, Kaufman HB, Zelenchuk A, Harper W, Burke GC, Burke EE, Harper DM.
J Biomed Opt
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p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
Authors: Authors: Zhang P, Wong C, Liu D, Finegold M, Harper JW, Elledge SJ.
Genes Dev
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Stuck in the middle: drugging the ubiquitin system at the e2 step.
Authors: Authors: Harper JW, King RW.
Cell
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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
Authors: Authors: Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ.
Science
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