Wade Harper, Ph.D.

Bert and Natalie Vallee Professor of Molecular Pathology, Harvard Medical School
617-432-6590
The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues.
Authors: Authors: Stepanova L, Finegold M, DeMayo F, Schmidt EV, Harper JW.
Mol Cell Biol
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Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome.
Authors: Authors: Zhang P, Liégeois NJ, Wong C, Finegold M, Hou H, Thompson JC, Silverman A, Harper JW, DePinho RA, Elledge SJ.
Nature
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The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.
Authors: Authors: Wei Y, Jin J, Harper JW.
Mol Cell Biol
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Culprits in the degradation of cyclin E apprehended.
Authors: Authors: Winston JT, Chu C, Harper JW.
Genes Dev
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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
Authors: Authors: Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ.
Cell
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Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
Authors: Authors: Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ.
Cell
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A family of mammalian F-box proteins.
Authors: Authors: Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW.
Curr Biol
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Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
Authors: Authors: Stepanova L, Leng X, Parker SB, Harper JW.
Genes Dev
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Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition.
Authors: Authors: Passmore LA, McCormack EA, Au SW, Paul A, Willison KR, Harper JW, Barford D.
EMBO J
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Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E.
Authors: Authors: Wang Y, Penfold S, Tang X, Hattori N, Riley P, Harper JW, Cross JC, Tyers M.
Curr Biol
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