Wade Harper, Ph.D.

Bert and Natalie Vallee Professor of Molecular Pathology, Harvard Medical School
617-432-6590
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.
Authors: Authors: Deng C, Zhang P, Harper JW, Elledge SJ, Leder P.
Cell
View full abstract on Pubmed
The anaphase-promoting complex: it's not just for mitosis any more.
Authors: Authors: Harper JW, Burton JL, Solomon MJ.
Genes Dev
View full abstract on Pubmed
SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex.
Authors: Authors: Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P.
Mol Cell
View full abstract on Pubmed
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
Authors: Authors: Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ.
Genes Dev
View full abstract on Pubmed
Efp: a ring of independence?
Authors: Authors: Nalepa G, Harper JW.
Nat Med
View full abstract on Pubmed
How the cyclin became a cyclin: regulated proteolysis in the cell cycle.
Authors: Authors: Koepp DM, Harper JW, Elledge SJ.
Cell
View full abstract on Pubmed
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells.
Authors: Authors: Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ.
Science
View full abstract on Pubmed
RING finger specificity in SCF-driven protein destruction.
Authors: Authors: Jin J, Harper JW.
Dev Cell
View full abstract on Pubmed
Skipping into the E2F1-destruction pathway.
Authors: Authors: Harper JW, Elledge SJ.
Nat Cell Biol
View full abstract on Pubmed
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Authors: Authors: Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ.
Cell
View full abstract on Pubmed