Zuzana Tothova, MD, PhD

Assistant Professor of Medicine, Dana-Farber Cancer Institute
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.
Authors: Authors: Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MAS, Scadden DT, Schreiber SL, Ebert BL, Golub TR.
Nat Chem Biol
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New strategies in myelodysplastic syndromes: application of molecular diagnostics to clinical practice.
Authors: Authors: Tothova Z, Steensma DP, Ebert BL.
Clin Cancer Res
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Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
Authors: Authors: Tothova Z, Wagner AJ.
Curr Opin Oncol
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AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Authors: Authors: Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Schöll C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT.
Cell
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Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
Authors: Authors: Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T.
Blood
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mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.
Authors: Authors: Lee JY, Nakada D, Yilmaz OH, Tothova Z, Joseph NM, Lim MS, Gilliland DG, Morrison SJ.
Cell Stem Cell
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A radical bailout strategy for cancer stem cells.
Authors: Authors: Tothova Z, Gilliland DG.
Cell Stem Cell
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FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.
Authors: Authors: Lee BH, Tothova Z, Levine RL, Anderson K, Buza-Vidas N, Cullen DE, McDowell EP, Adelsperger J, Fröhling S, Huntly BJ, Beran M, Jacobsen SE, Gilliland DG.
Cancer Cell
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Intergenerational epigenetic inheritance of cancer susceptibility in mammals.
Authors: Authors: Lesch BJ, Tothova Z, Morgan EA, Liao Z, Bronson RT, Ebert BL, Page DC.
Elife
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FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system.
Authors: Authors: Tothova Z, Gilliland DG.
Cell Stem Cell
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