Follow on Funding & Exits

CNS drug delivery by identifying small molecule inhibitors of a newly identified key regulator of the blood brain barrier

Next-generation AAV therapies for management of intractable chronic pain

Identifying novel therapeutic targets for treating pain and chronic itch

Evaluating splicing modulators for therapeutic impact in cohesin-mutant AML and MDS cells

A novel biologic and therapeutic target for the treatment of diabetes

Protein therapeutics for treatment of chronic and inflammatory pain

Small molecule modulators of bile acid metabolism to treat NAFLD/NASH

A high-throughput platform for the non-invasive intracellular delivery of molecules for therapeutic applications

Targeting apoptotic pathways for ALS, Alzheimer’s Disease and Parkinson’s Disease

Engineered proteins for treatment of pancreatitis

Methods and applications of semi-permeable capsules with current application to high-throughput single cell multi-omics

Identification of small molecule binders of the novel cancer immunotherapy target Bird33

A natural beta interferon-inducing therapeutic glycolipid from the microbiome that prevents and treats severe viral infection

Development of a new precision therapeutic for an important cancer target

Functional antibody screening with micro-capsules - proof of concept with anti-EGFR

Using microbiome-derived small molecules to augment cancer immunotherapy

Brain-penetrant kinase inhibitors targeting Alzheimer's and related dementias

Gene therapy for the treatment of Wolfram Syndrome II

Novel biologics for cancer therapy

Computationally designed therapy targeting lysosomal function and inflammation in neurodegenerative diseases

Restoring cortical function and plasticity for the treatment of Alzheimer’s Disease

Microtubule stabilizing drugs for neurodegenerative disease and spinal cord injury

Developing therapeutics for treating Rett syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation

Building better screens and identifying ligands for human MS4A proteins

Development of small molecule modulators of autophagy and ER stress as novel therapeutics for AD

Developing CRISPR-Cas9 reagents for editing lytic and latent herpes simplex virus genomes

Targeting neuro-immune signaling to treat bacterial infections

Isoguvacine and benzodiazepine derivatives for the treatment of tactile hypersensitivity and anxiety in autism spectrum disorders

Development of an inexpensive at-home influenza kit and detection technology

Development of AAV-mediated mini-gene therapy for Usher syndrome type 1F, a combined deafness and blindness

Development of synthetic analogs of a sleeve gastrectomy-induced metabolite as a novel therapy for type 2 diabetes and obesity

Target identification of neuroprotective kinase inhibitors for Alzheimer’s and related dementias