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Fiscal Year Awarded Principal Investigator
Development of allosteric activators for immunotherapy
2025 Stephen Blacklow
Targeting cell surface receptors for ASO delivery to bone marrow leukemia cells
2025 Karen Adelman
In vivo gene editing to treat inherited Collagen VI-related myopathies
2025 Amy Wagers
In vivo strategy to induce tolerance to therapeutic proteins and autoantigens
2025 Amy Wagers
Targeting cancers by de-repressing nuclear PDC
2025 David Scadden
Developing a synthetic biology platform for pharmaceutical biomanufacturing
2025 Pamela Silver
Oral pan-coronavirus anti-viral
2025 Timothy Mitchison
Developing a Biomarker of Homologous Recombination Deficiency for Enhanced PARP Inhibitor Efficacy Across Cancers
2025 Peter Park
Development of small molecule inhibitors of a gut bacterial metabolic toxin
2025 Sloan Devlin
Virome Screening for Next Generation Nucleic Acid Delivery Vectors to the Lung
2025 George Church
Investigating the mode of action of a highly selective insecticide and suitability for Anopheles management
2025 Norbert Perrimon
Structure-based discovery of chromatin remodeling inhibitors
2025 Lucas Farnung
Functional antibody screening with micro-capsules - proof of concept with anti-EGFR
2024 Allon Klein
Development of novel AAV-mediated in vivo gene editing approaches to treat inherited collagen VI-related myopathies
2024 Amy Wagers
Structure-based discovery and optimization of novel angiotensin receptor modulators
2024 Andrew Kruse
Identification of small molecule binders of the novel cancer immunotherapy target Bird33
2024 Arlene Sharpe
Gene editing to treat hereditary deafness
2024 David Corey
Development of a synthetic promoter pipeline for safe and efficient gene therapy
2024 George Church
Using microbiome-derived small molecules to augment cancer immunotherapy
2024 Marco Jost
Design of novel protease inhibitors to enhance immune checkpoint blockade in cancer therapy
2024 Mark Namchuk
Multimodal imaging and machine learning for diagnosis and patient stratification with predictive biomarkers
2024 Peter Sorger
Small molecule therapeutics for HPV associated cancers
2024 Peter Howley
Targeting tumor endothelial cells for cancer immunotherapy with cytokines
2024 Ulrich von Andrian
Manipulating mitobiogenesis by targeting ME2
2023 David Scadden
Methods and applications of semi-permeable capsules with current application to high-throughput single cell multi-omics
2023 Allon Klein
Developing novel agonists of cytokine receptors by targeting receptor pre-clusters
2023 James Chou
Evaluating antisense oligos for therapeutic impact in liver fibrosis and hepatocellular carcinoma
2023 Karen Adelman
Identification of druggable targets against Vibrio pathogens
2023 Norbert Perrimon
A kinase inhibitor for malignant brain tumors
2023 Timothy Mitchison
Agents modulating B cell activation through the CD81-CD19 co-receptor complex
2023 Stephen Blacklow
Brain-penetrant kinase inhibitors targeting Alzheimer's and related dementias
2023 Mark Albers
Antibody-based therapeutics against Nipah virus
2023 Jonathan Abraham
Enzyme prospecting for better diagnostics
2022 Michael Springer
A platform for transcriptome time-series in single cells with applications to hematopoietic stem cells
2022 Johan Paulsson
Small molecule drugs for advanced cancer with ecDNA amplicons
2022 Timothy Mitchison
Development of a novel monoclonal antibody that targets SARS-CoV-2 3a
2022 John Mekalanos
CNS drug delivery by identifying small molecule inhibitors of a newly identified key regulator of the blood brain barrier
2022 Chenghua Gu
Studies on immunogenic lipids from the gut microbiome
2022 Jon Clardy
Novel biologics for cancer therapy
2022 George Church
Gene therapy for the treatment of Wolfram Syndrome II
2022 Amy Wagers
A natural beta interferon-inducing therapeutic glycolipid from the microbiome that prevents and treats severe viral infection
2022 Dennis Kasper
Small molecule modulators of bile acid metabolism to treat NAFLD/NASH
2022 Sloan Devlin
Structure-guided discovery of novel antibiotics inhibiting bacterial cell wall formation
2021 Maofu Liao
Identifying novel therapeutic targets for treating pain and chronic itch
2021 David Ginty
Target identification of neuroprotective kinase inhibitors for Alzheimer’s and related dementias
2021 Mark Albers
Protein therapeutics for treatment of chronic and inflammatory pain
2021 Pamela Silver
Evaluating splicing modulators for therapeutic impact in cohesin-mutant AML and MDS cells
2021 Karen Adelman
Development of an inexpensive at-home influenza kit and detection technology
2021 Michael Springer
A novel biologic and therapeutic target for the treatment of diabetes
2021 Douglas Melton
Application of the SPLANDID antigen presentation technology to HIV-1 vaccine development
2021 James Chou