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Fiscal Year Awarded Principal Investigator
Evaluating splicing modulators for therapeutic impact in cohesin-mutant AML and MDS cells
2020 Karen Adelman
Target validation and in vivo testing of a broad-spectrum antiviral
2020 Priscilla Yang
A high-throughput platform for the non-invasive intracellular delivery of molecules for therapeutic applications
2020 Johan Paulsson
Multiplex editing the human genome
2020 George Church
Engineered proteins for treatment of pancreatitis
2020 Pamela Silver
Interleukin-17 as a novel erythropoiesis stimulating agent
2020 Allon Klein
Developing novel therapeutic approaches for CNS drug delivery by targeting a newly identified key regulator of the blood brain barrier
2020 Chenghua Gu
Next-generation AAV therapies for management of intractable chronic pain
2020 Michael Greenberg
Development of synthetic analogs of a sleeve gastrectomy-induced metabolite as a novel therapy for type 2 diabetes and obesity
2020 Sloan Devlin
Targeting apoptotic pathways for ALS, Alzheimer’s Disease and Parkinson’s Disease
2020 Bruce Bean
Monoclonal antibody-based therapeutics for Argentine hemorrhagic fever
2020 Jonathan Abraham
A novel system for rational discovery of polycystic kidney disease therapeutics
2019 Adrian Salic
Computationally designed therapy targeting lysosomal function and inflammation in neurodegenerative diseases
2019 Peter Park
Small molecule modulators of gut bacterial bile acid metabolism to treat metabolic syndrome and associated non-alcoholic fatty liver disease (NAFLD)
2019 Sloan Devlin
Development of an inexpensive at-home influenza kit and detection technology
2019 Michael Springer
Development of AAV-mediated mini-gene therapy for Usher syndrome type 1F, a combined deafness and blindness
2019 David Corey
Development of new antiviral compounds
2019 Donald Coen
Development of a new precision therapeutic for an important cancer target
2019 Stephen Blacklow
Targeting neuro-immune signaling to treat bacterial infections
2019 Isaac Chiu
Isoguvacine and benzodiazepine derivatives for the treatment of tactile hypersensitivity and anxiety in autism spectrum disorders
2019 David Ginty
Developing CRISPR-Cas9 reagents for editing lytic and latent herpes simplex virus genomes
2018 David Knipe
Development of small molecule modulators of autophagy and ER stress as novel therapeutics for AD
2018 Junying Yuan
Identification of dengue virus inhibitors
2018 Priscilla Yang
Developing therapeutics for treating Rett Syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation
2018 Michael Greenberg
Developing therapeutics for treating Rett syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation
2017 Michael Greenberg
Microtubule stabilizing drugs for neurodegenerative disease and spinal cord injury
2017 Timothy Mitchison
Building better screens and identifying ligands for human MS4A proteins
2017 Sandeep Datta
Assessment of targeted protein degradation as a strategy for potent antivirals with high barriers to resistance
2017 Priscilla Yang
Restoring cortical function and plasticity for the treatment of Alzheimer’s Disease
2017 Bernardo Sabatini
Developing a ubiquitin-dependent proteasome activity reporter to screen for activators and inhibitors
2017 Marc Kirschner