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Fiscal Year Awarded
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Principal Investigator
Computationally designed therapy targeting lysosomal function and inflammation in neurodegenerative diseases
2019
Peter Park
Small molecule modulators of gut bacterial bile acid metabolism to treat metabolic syndrome and associated non-alcoholic fatty liver disease (NAFLD)
2019
Abigail Devlin
Development of an inexpensive at-home influenza kit and detection technology
2019
Michael Springer
Development of AAV-mediated mini-gene therapy for Usher syndrome type 1F, a combined deafness and blindness
2019
David Corey
Development of new antiviral compounds
2019
Donald Coen
Development of a new precision therapeutic for an important cancer target
2019
Stephen Blacklow
Targeting neuro-immune signaling to treat bacterial infections
2019
Isaac Chiu
Isoguvacine and benzodiazepine derivatives for the treatment of tactile hypersensitivity and anxiety in autism spectrum disorders
2019
David Ginty
Developing CRISPR-Cas9 reagents for editing lytic and latent herpes simplex virus genomes
2018
David Knipe
Development of small molecule modulators of autophagy and ER stress as novel therapeutics for AD
2018
Junying Yuan
Identification of dengue virus inhibitors
2018
Priscilla Yang
Developing therapeutics for treating Rett Syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation
2018
Michael Greenberg
Developing therapeutics for treating Rett syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation
2017
Michael Greenberg
Microtubule stabilizing drugs for neurodegenerative disease and spinal cord injury
2017
Timothy Mitchison
Building better screens and identifying ligands for human MS4A proteins
2017
Sandeep Datta
Assessment of targeted protein degradation as a strategy for potent antivirals with high barriers to resistance
2017
Priscilla Yang
Restoring cortical function and plasticity for the treatment of Alzheimer’s Disease
2017
Bernardo Sabatini
Developing a ubiquitin-dependent proteasome activity reporter to screen for activators and inhibitors
2017
Marc Kirschner
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