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Fiscal Year Awarded Principal Investigator
A natural beta interferon-inducing therapeutic glycolipid from the microbiome that prevents and treats severe viral infection
2022 Dennis Kasper
Gene therapy for the treatment of Wolfram Syndrome II
2022 Amy Wagers
Novel biologics for cancer therapy
2022 George Church
Studies on immunogenic lipids from the gut microbiome
2022 Jon Clardy
Application of the SPLANDID antigen presentation technology to HIV-1 vaccine development
2021 James Chou
A novel biologic and therapeutic target for the treatment of diabetes
2021 Douglas Melton
Development of an inexpensive at-home influenza kit and detection technology
2021 Michael Springer
Evaluating splicing modulators for therapeutic impact in cohesin-mutant AML and MDS cells
2021 Karen Adelman
Protein therapeutics for treatment of chronic and inflammatory pain
2021 Pamela Silver
Target identification of neuroprotective kinase inhibitors for Alzheimer’s and related dementias
2021 Mark Albers
Identifying novel therapeutic targets for treating pain and chronic itch
2021 David Ginty
Structure-guided discovery of novel antibiotics inhibiting bacterial cell wall formation
2021 Maofu Liao
Evaluating splicing modulators for therapeutic impact in cohesin-mutant AML and MDS cells
2020 Karen Adelman
Monoclonal antibody-based therapeutics for Argentine hemorrhagic fever
2020 Jonathan Abraham
Targeting apoptotic pathways for ALS, Alzheimer’s Disease and Parkinson’s Disease
2020 Bruce Bean
Development of synthetic analogs of a sleeve gastrectomy-induced metabolite as a novel therapy for type 2 diabetes and obesity
2020 Sloan Devlin
Next-generation AAV therapies for management of intractable chronic pain
2020 Michael Greenberg
Developing novel therapeutic approaches for CNS drug delivery by targeting a newly identified key regulator of the blood brain barrier
2020 Chenghua Gu
Interleukin-17 as a novel erythropoiesis stimulating agent
2020 Allon Klein
Engineered proteins for treatment of pancreatitis
2020 Pamela Silver
Multiplex editing the human genome
2020 George Church
A high-throughput platform for the non-invasive intracellular delivery of molecules for therapeutic applications
2020 Johan Paulsson
Target validation and in vivo testing of a broad-spectrum antiviral
2020 Priscilla Yang
Targeting neuro-immune signaling to treat bacterial infections
2019 Isaac Chiu
Development of a new precision therapeutic for an important cancer target
2019 Stephen Blacklow
A novel system for rational discovery of polycystic kidney disease therapeutics
2019 Adrian Salic
Development of new antiviral compounds
2019 Donald Coen
Development of AAV-mediated mini-gene therapy for Usher syndrome type 1F, a combined deafness and blindness
2019 David Corey
Development of an inexpensive at-home influenza kit and detection technology
2019 Michael Springer
Small molecule modulators of gut bacterial bile acid metabolism to treat metabolic syndrome and associated non-alcoholic fatty liver disease (NAFLD)
2019 Sloan Devlin
Computationally designed therapy targeting lysosomal function and inflammation in neurodegenerative diseases
2019 Peter Park
Isoguvacine and benzodiazepine derivatives for the treatment of tactile hypersensitivity and anxiety in autism spectrum disorders
2019 David Ginty
Developing therapeutics for treating Rett Syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation
2018 Michael Greenberg
Identification of dengue virus inhibitors
2018 Priscilla Yang
Development of small molecule modulators of autophagy and ER stress as novel therapeutics for AD
2018 Junying Yuan
Developing CRISPR-Cas9 reagents for editing lytic and latent herpes simplex virus genomes
2018 David Knipe
Developing therapeutics for treating Rett syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation
2017 Michael Greenberg
Developing a ubiquitin-dependent proteasome activity reporter to screen for activators and inhibitors
2017 Marc Kirschner
Restoring cortical function and plasticity for the treatment of Alzheimer’s Disease
2017 Bernardo Sabatini
Assessment of targeted protein degradation as a strategy for potent antivirals with high barriers to resistance
2017 Priscilla Yang
Building better screens and identifying ligands for human MS4A proteins
2017 Sandeep Datta
Microtubule stabilizing drugs for neurodegenerative disease and spinal cord injury
2017 Timothy Mitchison