Q-FASTR Records

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	Fiscal Year Awarded	Principal Investigator
Target validation and in vivo testing of a broad-spectrum antiviral	2020	Priscilla Yang
Targeting apoptotic pathways for ALS, Alzheimer’s Disease and Parkinson’s Disease	2020	Bruce Bean
A novel system for rational discovery of polycystic kidney disease therapeutics	2019	Adrian Salic
Computationally designed therapy targeting lysosomal function and inflammation in neurodegenerative diseases	2019	Peter Park
Development of a new precision therapeutic for an important cancer target	2019	Stephen Blacklow
Development of AAV-mediated mini-gene therapy for Usher syndrome type 1F, a combined deafness and blindness	2019	David Corey
Development of an inexpensive at-home influenza kit and detection technology	2019	Michael Springer
Development of new antiviral compounds	2019	Donald Coen
Isoguvacine and benzodiazepine derivatives for the treatment of tactile hypersensitivity and anxiety in autism spectrum disorders	2019	David Ginty
Small molecule modulators of gut bacterial bile acid metabolism to treat metabolic syndrome and associated non-alcoholic fatty liver disease (NAFLD)	2019	Sloan Devlin
Targeting neuro-immune signaling to treat bacterial infections	2019	Isaac Chiu
Developing CRISPR-Cas9 reagents for editing lytic and latent herpes simplex virus genomes	2018	David Knipe
Developing therapeutics for treating Rett Syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation	2018	Michael Greenberg
Development of small molecule modulators of autophagy and ER stress as novel therapeutics for AD	2018	Junying Yuan
Identification of dengue virus inhibitors	2018	Priscilla Yang
Assessment of targeted protein degradation as a strategy for potent antivirals with high barriers to resistance	2017	Priscilla Yang
Building better screens and identifying ligands for human MS4A proteins	2017	Sandeep Datta
Developing a ubiquitin-dependent proteasome activity reporter to screen for activators and inhibitors	2017	Marc Kirschner
Developing therapeutics for treating Rett syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation	2017	Michael Greenberg
Microtubule stabilizing drugs for neurodegenerative disease and spinal cord injury	2017	Timothy Mitchison

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